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XB-ART-4281
Matrix Biol 2003 Nov 01;226:511-7. doi: 10.1016/s0945-053x(03)00082-9.
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Molecular cloning, genomic organization and developmental expression of the Xenopus laevis hyaluronan synthase 3.

Vigetti D , Viola M , Gornati R , Ori M , Nardi I , Passi A , De Luca G , Bernardini G .


Abstract
The content of hyaluronan (HA), a polymer of the extracellular matrix involved in a variety of physiological and pathological processes, depends on the activity of synthetic (HAS) and degrading enzymes. Since HA is also involved in embryogenesis, we have used Xenopus as a model organism because information is available for HAS1 and HAS2, but not for HAS3. We report the sequence of xlHAS3 mRNA, its genomic organization and its expression in adult tissues as well as during embryonic development. Interestingly, evidence from in situ hybridization indicates that xlHAS3 expression is restricted to the developing inner ear and cement gland. In addition, we have correlated the expression pattern of the enzymes involved in HA metabolism with the HA content during development.

PubMed ID: 14667843
Article link: Matrix Biol


Species referenced: Xenopus laevis
Genes referenced: has1 has2 has3


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