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Dev Dyn 2011 Sep 01;2409:2120-6. doi: 10.1002/dvdy.22701.
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Regulation of early Xenopus development by the PIAS genes.

Burn B , Brown S , Chang C .

Originally identified as cytokine inhibitors, protein inhibitors of activated STAT (PIAS) are shown to regulate activities of a plethora of proteins and influence diverse processes such as immune response, cancer formation, and cell cycle progression. However, the roles of PIAS during vertebrate embryogenesis are less understood. In this study, we report isolation and initial characterization of all four PIAS genes from Xenopus laevis. The Xenopus PIAS genes are expressed throughout early development and have overlapping and distinct expression patterns, with, for example, high levels of PIAS2 in the notochord and strong expression of PIAS4 in the neural and neural crest derivatives. Overexpression of PIAS disrupts mesoderm induction and impairs body axis formation. PIAS proteins have differential ability to regulate signals from the growth factors activin, bone morphogenetic protein 4 (BMP4), and Wnt8. Our data suggest that Xenopus PIAS play important roles in mesodermal induction and patterning during early frog development.

PubMed ID: 21780242
PMC ID: PMC3192905
Article link: Dev Dyn
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: actl6a apcs bmp4 chrd myod1 pias1 pias2 pias3 pias4 tbxt wnt8a

Article Images: [+] show captions
References [+] :
Arora, PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4. 2003, Pubmed