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Biochem Biophys Res Commun 2011 Nov 11;4151:11-6. doi: 10.1016/j.bbrc.2011.09.138.
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The homeobox leucine zipper gene Homez plays a role in Xenopus laevis neurogenesis.

Ghimouz R , Bar I , Hanotel J , Minela B , Keruzore M , Thelie A , Bellefroid EJ .

The Homez gene encodes a protein with three atypical homeodomains and two leucine zipper motifs of unknown function. Here we show that during neurula stages, Xenopus Homez is broadly expressed throughout the neural plate, the strongest expression being detected in the domains where primary neurons arise. At later stages, Homez is maintained throughout the central nervous system in differentiating progenitors. In accordance with this expression, Homez is positively regulated by neural inducers and by Ngnr1 and negatively by Notch signaling. Interference with Homez function in embryos by injection of an antisense morpholino oligonucleotide results in the specific disruption of the expression of late neuronal markers, without affecting the expression of earlier neuronal and early neurectodermal markers. Consistent with this finding, Homez inhibition also interferes with the expression of late neuronal markers in Ngnr1 overexpressing animal cap explants and in Notch inhibited embryos. In gain of function experiments, Homez inhibits the expression of late neuronal markers but has no effect on earlier ones. These data suggest a role for Homez in neuronal development downstream of proneural/neurogenic genes.

PubMed ID: 22001922
Article link: Biochem Biophys Res Commun

Species referenced: Xenopus laevis
Genes referenced: btbd6 dmrta2 dpysl3 foxi1 homez krt12.4 myc myt1 neurog1 neurog2 nog nos1 notch1 sox3 tbxt tcf3 tubb2b vegt
Morpholinos: homez MO1

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