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XB-ART-45314
ScientificWorldJournal 2012 Jan 01;2012:689287. doi: 10.1100/2012/689287.
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Molecular cloning of phd1 and comparative analysis of phd1, 2, and 3 expression in Xenopus laevis.

Han D , Wen L , Chen Y .


Abstract
Intensive gene targeting studies in mice have revealed that prolyl hydroxylase domain proteins (PHDs) play important roles in murine embryonic development; however, the expression patterns and function of these genes during embryogenesis of other vertebrates remain largely unknown. Here we report the molecular cloning of phd1 and systematic analysis of phd1, phd2, and phd3 expression in embryos as well as adult tissues of Xenopus laevis. All three phds are maternally provided during Xenopus early development. The spatial expression patterns of phds genes in Xenopus embryos appear to define a distinct synexpression group. Frog phd2 and phd3 showed complementary expression in adult tissues with phd2 transcription levels being high in the eye, brain, and intestine, but low in the liver, pancreas, and kidney. On the contrary, expression levels of phd3 are high in the liver, pancreas, and kidney, but low in the eye, brain, and intestine. All three phds are highly expressed in testes, ovary, gall bladder, and spleen. Among three phds, phd3 showed strongest expression in heart.

PubMed ID: 22645445
PMC ID: PMC3356726
Article link: ScientificWorldJournal


Species referenced: Xenopus laevis
Genes referenced: egln1 egln2 egln3 odc1


Article Images: [+] show captions
References [+] :
Aragonés, Oxygen sensors at the crossroad of metabolism. 2009, Pubmed