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Dev Biol 2012 Jul 01;3671:55-65. doi: 10.1016/j.ydbio.2012.04.025.
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Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning.

Steventon B , Mayor R , Streit A .

In the vertebrate head, central and peripheral components of the sensory nervous system have different embryonic origins, the neural plate and sensory placodes. This raises the question of how they develop in register to form functional sense organs and sensory circuits. Here we show that mutual repression between the homeobox transcription factors Gbx2 and Otx2 patterns the placode territory by influencing regional identity and by segregating inner ear and trigeminal progenitors. Activation of Otx2 targets is necessary for anterior olfactory, lens and trigeminal character, while Gbx2 function is required for the formation of the posterior otic placode. Thus, like in the neural plate antagonistic interaction between Otx2 and Gbx2 establishes positional information thus providing a general mechanism for rostro-caudal patterning of the ectoderm. Our findings support the idea that the Otx/Gbx boundary has an ancient evolutionary origin to which different modules were recruited to specify cells of different fates.

PubMed ID: 22564795
PMC ID: PMC3384001
Article link: Dev Biol
Grant support: [+]

Species referenced: Xenopus
Genes referenced: dmrta1 en1 eya1 eya2 fdx1 foxe3 gbx2 gbx2.2 mst1 otx2 pax2 pax3 pax6 pax8 pdf runx3 tbx2
Antibodies: Otx2 Ab3 Pax3 Ab1
Morpholinos: gbx2.1 MO1 gbx2.2 MO1

Article Images: [+] show captions
References [+] :
Acampora, Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation. 1995, Pubmed