Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Development 2012 Jul 01;13913:2267-82. doi: 10.1242/dev.070110.
Show Gene links Show Anatomy links

The Prdm family: expanding roles in stem cells and development.

Hohenauer T , Moore AW .

Members of the Prdm family are characterized by an N-terminal PR domain that is related to the SET methyltransferase domain, and multiple zinc fingers that mediate sequence-specific DNA binding and protein-protein interactions. Prdm factors either act as direct histone methyltransferases or recruit a suite of histone-modifying enzymes to target promoters. In this way, they function in many developmental contexts to drive and maintain cell state transitions and to modify the activity of developmental signalling pathways. Here, we provide an overview of the structure and function of Prdm family members and discuss the roles played by these proteins in stem cells and throughout development.

PubMed ID: 22669819
Article link: Development

Genes referenced: ctbp2 ep300 kmt2b maml1 myf5 notch1 prdm1 prdm10 prdm11 prdm12 prdm13 prdm14 prdm15 prdm16 prdm2 prdm4 prdm5 prdm6 prdm8 tff3.1 vsx2 XB5904899

Article Images: [+] show captions