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Int J Dev Biol 2013 Jan 01;579-10:787-92. doi: 10.1387/ijdb.130080sm.
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Kidins220/ARMS is dynamically expressed during Xenopus laevis development.

Marracci S , Giannini M , Vitiello M , Andreazzoli M , Dente L .

Kidins220 (Kinase D interacting substrate of 220 kDa)/ARMS (Ankyrin Repeat-rich Membrane Spanning) is a conserved scaffold protein that acts as a downstream substrate for protein kinase D and mediates multiple receptor signalling pathways. Despite the dissecting of the function of this protein in mammals, using both in vitro and in vivo studies, a detailed characterization of its gene expression during early phases of embryogenesis has not been described yet. Here, we have used Xenopus laevis as a vertebrate model system to analyze the gene expression and the protein localization of Kidins220/ARMS. We found its expression was dynamically regulated during development. Kidins220/ARMS mRNA was expressed from neurula to larval stage in different embryonic regions including the nervous system, eye, branchial arches, heart and somites. Similar to the transcript, the protein was present in multiple embryonic domains including the central nervous system, cranial nerves, motor nerves, intersomitic junctions, retinal ganglion cells, lens, otic vesicle, heart and branchial arches. In particular, in some regions such as the retina and somites, the protein displayed a differential localization pattern in stage 42 embryos when compared to the earlier examined stages. Taken together our results suggest that this multidomain protein is involved in distinct spatio-temporal differentiative events.

PubMed ID: 24307304
Article link: Int J Dev Biol

Species referenced: Xenopus laevis
Genes referenced: ank1 kidins220 mhc2-dab myos tub tuba4b
Antibodies: GFAP Ab2 Kidins220 Ab1 Somite Ab1 Tuba4b Ab4

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