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Neural Dev 2013 Sep 17;8:18. doi: 10.1186/1749-8104-8-18.
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The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons.

Schmeisser MJ , Kühl SJ , Schoen M , Beth NH , Weis TM , Grabrucker AM , Kühl M , Boeckers TM .

BACKGROUND: Circuit formation in the nervous system essentially relies on the proper development of neurons and their processes. In this context, the ubiquitin ligase Nedd4 is a crucial modulator of axonal and dendritic branching. RESULTS: Herein we characterize the Nedd4-binding protein 3 (N4BP3), a Fezzin family member, during nerve cell development. In developing rat primary hippocampal neurons, endogenous N4BP3 localizes to neuronal processes, including axons and dendrites. Transient in vitro knockdown of N4BP3 in hippocampal cultures during neuritogenesis results in impaired branching of axons and dendrites. In line with these findings, in vivo knockdown of n4bp3 in Xenopus laevis embryos results in severe alteration of cranial nerve branching. CONCLUSIONS: We introduce N4BP3 as a novel molecular element for the correct branching of neurites in developing neurons and propose a central role for an N4BP3-Nedd4 complex in neurite branching and circuit formation.

PubMed ID: 24044555
PMC ID: PMC3849298
Article link: Neural Dev

Species referenced: Xenopus laevis
Genes referenced: actl6a fez1 map2 myc n4bp3 nedd4 noct ugcg
Antibodies: N4bp3 Ab1 Neuronal Ab4
Morpholinos: n4bp3 MO1

Article Images: [+] show captions
References [+] :
Brandt, The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity. 2007, Pubmed