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Mol Cells 2014 Oct 31;3710:705-12. doi: 10.14348/molcells.2014.0227.
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Neural transcription factors: from embryos to neural stem cells.

Lee HK , Lee HS , Moody SA .

The early steps of neural development in the vertebrate embryo are regulated by sets of transcription factors that control the induction of proliferative, pluripotent neural precursors, the expansion of neural plate stem cells, and their transition to differentiating neural progenitors. These early events are critical for producing a pool of multipotent cells capable of giving rise to the multitude of neurons and glia that form the central nervous system. In this review we summarize findings from gain- and loss-of-function studies in embryos that detail the gene regulatory network responsible for these early events. We discuss whether this information is likely to be similar in mammalian embryonic and induced pluripotent stem cells that are cultured according to protocols designed to produce neurons. The similarities and differences between the embryo and stem cells may provide important guidance to stem cell protocols designed to create immature neural cells for therapeutic uses.

PubMed ID: 25234468
PMC ID: PMC4213760
Article link: Mol Cells
Grant support: [+]

Species referenced: Xenopus
Genes referenced: atf2 bmi1 ctnnb1 dvl1 dvl2 e2f1 fgf2 foxd4l1.1 gli1 gmnn hes1 mapk8 notch1 shh smo sox11 zic2

Article Images: [+] show captions
References [+] :
Ahmed, Transcription factors and neural stem cell self-renewal, growth and differentiation. 2009, Pubmed