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Figure 1. Specific expression of microRNAs in ciliated cell types. The miR-34/449 family is expressed in mucociliary multiciliated cells, where it inhibits cp110 to promote ciliogenesis of motile cilia (left). miR-129 is required for inhibition of cp110 and ciliogenesis of motile mono-cilia (middle). The miR-183 family is expressed in non-motile ciliated neurosensory cells, but their precise role is not elucidated yet (right).
Cao,
miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics.
2012, Pubmed
Cao,
miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics.
2012,
Pubmed
Christodoulou,
Ancient animal microRNAs and the evolution of tissue identity.
2010,
Pubmed
Marcet,
Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway.
2011,
Pubmed
,
Xenbase
Pierce,
MicroRNA-183 family conservation and ciliated neurosensory organ expression.
2008,
Pubmed
Solberg,
Airway epithelial miRNA expression is altered in asthma.
2012,
Pubmed
Song,
miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110.
2014,
Pubmed
,
Xenbase
Wang,
miR-34b regulates multiciliogenesis during organ formation in zebrafish.
2013,
Pubmed
