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Dev Dyn 2015 Oct 01;24410:1328-46. doi: 10.1002/dvdy.24310.
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Kruppel-like factor family genes are expressed during Xenopus embryogenesis and involved in germ layer formation and body axis patterning.

Gao Y , Cao Q , Lu L , Zhang X , Zhang Z , Dong X , Jia W , Cao Y .

BACKGROUND: Kruppel-like factors (Klfs) are a family of transcription factors consisting of 17 members in mammals, Klf1-Klf17, which are involved in fundamental cellular physiological procedures, such as cell proliferation, differentiation, and apoptosis. However, their functions in embryonic development have been poorly understood. Our previous study has demonstrated that the pluripotency factor Klf4 participates in germ layer formation and axis patterning of Xenopus embryos by means of the regulation of key developmental signals. In the present study, we further investigated comprehensively the expression and functions of the klf family genes, klf2, klf5, klf6, klf7, klf8, klf11, klf15, and klf17, during the embryogenesis of Xenopus laevis. RESULTS: Spatio-temporal expression analyses demonstrate that these genes are transcribed both maternally and zygotically in Xenopus embryos, and during organogenesis and tissue differentiation, they are localized to a variety of placodes and tissues. Gain and loss of function studies manifest that Klf factors play different roles in germ layer formation and body axis patterning. Moreover, each Klf factor exhibits distinct regulatory effects on the expression of genes that are essential for germ layer formation and body axis patterning. CONCLUSIONS: These results suggest that Klf factors are involved in the fine-tuning of these genes during early embryogenesis.

PubMed ID: 26198170
Article link: Dev Dyn

Species referenced: Xenopus laevis
Genes referenced: cer1 chrd dkk1 foxa4 foxi1 gsc klf10 klf11 klf12 klf13 klf15 klf17 klf2 klf3 klf4 klf5 klf6 klf7 klf8 klf9 lhx1 nodal nodal5 odc1 prnp sox17a sox2 sox3 tbl1x tbxt trim33 vegt wnt8a wnt8b
Morpholinos: klf11 MO2 klf15 MO1 klf2 MO2 klf5 MO1 klf6 MO1 klf7 MO1 klf8 MO2

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