Fu J , Hagan IM , Glover DM .

11431 Cancer Research UK, CRUK_11431 Cancer Research UK, 16406 Cancer Research UK, 18795 Cancer Research UK

Abrieu, The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs. 1998, Pubmed, Xenbase

Abrieu, The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs. 1998, Pubmed , Xenbase
Adames, Microtubule interactions with the cell cortex causing nuclear movements in Saccharomyces cerevisiae. 2000, Pubmed
Adams, Localization of core spindle pole body (SPB) components during SPB duplication in Saccharomyces cerevisiae. 1999, Pubmed
Adams, Spindle pole body duplication: a model for centrosome duplication? 2000, Pubmed
Alfa, Distinct nuclear and spindle pole body population of cyclin-cdc2 in fission yeast. 1990, Pubmed
Anderson, Centriole age underlies asynchronous primary cilium growth in mammalian cells. 2009, Pubmed
Archinti, SPICE--a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression. 2010, Pubmed
Arquint, STIL microcephaly mutations interfere with APC/C-mediated degradation and cause centriole amplification. 2014, Pubmed
Arquint, Cell-cycle-regulated expression of STIL controls centriole number in human cells. 2012, Pubmed
Avasthi, Stages of ciliogenesis and regulation of ciliary length. 2012, Pubmed
Azimzadeh, Centrosome loss in the evolution of planarians. 2012, Pubmed
Azimzadeh, hPOC5 is a centrin-binding protein required for assembly of full-length centrioles. 2009, Pubmed
Bahe, Rootletin forms centriole-associated filaments and functions in centrosome cohesion. 2005, Pubmed
Bahtz, GCP6 is a substrate of Plk4 and required for centriole duplication. 2012, Pubmed
Bailly, p34cdc2 is located in both nucleus and cytoplasm; part is centrosomally associated at G2/M and enters vesicles at anaphase. 1989, Pubmed
Balestra, Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells. 2013, Pubmed
Bardin, A mechanism for coupling exit from mitosis to partitioning of the nucleus. 2000, Pubmed
Barr, CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response. 2010, Pubmed
Barros, Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules. 2005, Pubmed , Xenbase
Baum, Yeast gene required for spindle pole body duplication: homology of its product with Ca2+-binding proteins. 1986, Pubmed
Beach, The role of the proteins Kar9 and Myo2 in orienting the mitotic spindle of budding yeast. 2000, Pubmed
Bertazzi, The cortical protein Lte1 promotes mitotic exit by inhibiting the spindle position checkpoint kinase Kin4. 2011, Pubmed
Bettencourt-Dias, SAK/PLK4 is required for centriole duplication and flagella development. 2005, Pubmed
Biggins, Direct interaction between yeast spindle pole body components: Kar1p is required for Cdc31p localization to the spindle pole body. 1994, Pubmed
Blagden, Polar expeditions--provisioning the centrosome for mitosis. 2003, Pubmed
Bridge, The fission yeast SPB component Cut12 links bipolar spindle formation to mitotic control. 1998, Pubmed
Brito, Deconstructing the centriole: structure and number control. 2012, Pubmed
Brownlee, The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification. 2011, Pubmed
Bullitt, The yeast spindle pole body is assembled around a central crystal of Spc42p. 1997, Pubmed
Byers, Duplication of spindle plaques and integration of the yeast cell cycle. 1974, Pubmed
Byers, Behavior of spindles and spindle plaques in the cell cycle and conjugation of Saccharomyces cerevisiae. 1975, Pubmed
Cabral, Multiple mechanisms contribute to centriole separation in C. elegans. 2013, Pubmed
Carminati, Microtubules orient the mitotic spindle in yeast through dynein-dependent interactions with the cell cortex. 1997, Pubmed
Carvalho-Santos, Stepwise evolution of the centriole-assembly pathway. 2010, Pubmed
Caydasi, SPOC alert--when chromosomes get the wrong direction. 2012, Pubmed
Caydasi, Spindle alignment regulates the dynamic association of checkpoint proteins with yeast spindle pole bodies. 2009, Pubmed
Caydasi, The 14-3-3 protein Bmh1 functions in the spindle position checkpoint by breaking Bfa1 asymmetry at yeast centrosomes. 2014, Pubmed
Chang, Mitotic trigger waves and the spatial coordination of the Xenopus cell cycle. 2013, Pubmed , Xenbase
Chen, CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. 2002, Pubmed
Choi, CDK5RAP2 stimulates microtubule nucleation by the gamma-tubulin ring complex. 2010, Pubmed
Cizmecioglu, Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome. 2010, Pubmed
Comartin, CEP120 and SPICE1 cooperate with CPAP in centriole elongation. 2013, Pubmed
Conduit, Cnn dynamics drive centrosome size asymmetry to ensure daughter centriole retention in Drosophila neuroblasts. 2010, Pubmed
Conduit, Centrioles regulate centrosome size by controlling the rate of Cnn incorporation into the PCM. 2010, Pubmed
Conduit, The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation. 2014, Pubmed
Conduit, A molecular mechanism of mitotic centrosome assembly in Drosophila. 2014, Pubmed
Cormier, The PN2-3 domain of centrosomal P4.1-associated protein implements a novel mechanism for tubulin sequestration. 2009, Pubmed
Cottee, SAS-6 oligomerization: the key to the centriole? 2011, Pubmed
Cottee, Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly. 2013, Pubmed
Cunha-Ferreira, The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4. 2009, Pubmed
D'Angiolella, SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. 2010, Pubmed
D'Aquino, The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. 2005, Pubmed
Dammermann, SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules. 2008, Pubmed
Dammermann, Centriole assembly requires both centriolar and pericentriolar material proteins. 2004, Pubmed , Xenbase
De Souza, Centrosomal and cytoplasmic Cdc2/cyclin B1 activation precedes nuclear mitotic events. 2000, Pubmed
Decker, Limiting amounts of centrosome material set centrosome size in C. elegans embryos. 2011, Pubmed
Delattre, Centriolar SAS-5 is required for centrosome duplication in C. elegans. 2004, Pubmed
Delattre, Sequential protein recruitment in C. elegans centriole formation. 2006, Pubmed
Delgehyr, Klp10A, a microtubule-depolymerizing kinesin-13, cooperates with CP110 to control Drosophila centriole length. 2012, Pubmed
Dix, Drosophila Spd-2 recruits PCM to the sperm centriole, but is dispensable for centriole duplication. 2007, Pubmed
Dobbelaere, A genome-wide RNAi screen to dissect centriole duplication and centrosome maturation in Drosophila. 2008, Pubmed
Donaldson, Spc42p: a phosphorylated component of the S. cerevisiae spindle pole body (SPD) with an essential function during SPB duplication. 1996, Pubmed
Dutertre, Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition. 2004, Pubmed , Xenbase
Dzhindzhev, Plk4 phosphorylates Ana2 to trigger Sas6 recruitment and procentriole formation. 2014, Pubmed
Dzhindzhev, Asterless is a scaffold for the onset of centriole assembly. 2010, Pubmed
Elliott, Spc29p is a component of the Spc110p subcomplex and is essential for spindle pole body duplication. 1999, Pubmed
Erlemann, An extended γ-tubulin ring functions as a stable platform in microtubule nucleation. 2012, Pubmed
Falk, Lte1 promotes mitotic exit by controlling the localization of the spindle position checkpoint kinase Kin4. 2011, Pubmed
Fantes, Epistatic gene interactions in the control of division in fission yeast. 1979, Pubmed
Faragher, Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles. 2003, Pubmed
Ferenz, Mitotic functions of kinesin-5. 2010, Pubmed
Ferguson, Cyclin E-dependent localization of MCM5 regulates centrosome duplication. 2008, Pubmed , Xenbase
Ferguson, The cyclin A centrosomal localization sequence recruits MCM5 and Orc1 to regulate centrosome reduplication. 2010, Pubmed
Ferrell, Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses. 2008, Pubmed , Xenbase
Finst, Genetics of the deflagellation pathway in Chlamydomonas. 1998, Pubmed
Finst, Fa1p is a 171 kDa protein essential for axonemal microtubule severing in Chlamydomonas. 2000, Pubmed
Firat-Karalar, Proximity interactions among centrosome components identify regulators of centriole duplication. 2014, Pubmed
Fish, Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells. 2006, Pubmed
Fisk, The mouse Mps1p-like kinase regulates centrosome duplication. 2001, Pubmed
Fisk, Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression. 2003, Pubmed
Flory, Pcp1p, an Spc110p-related calmodulin target at the centrosome of the fission yeast Schizosaccharomyces pombe. 2002, Pubmed
Fong, CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex. 2008, Pubmed
Fong, SAS-6 assembly templated by the lumen of cartwheel-less centrioles precedes centriole duplication. 2014, Pubmed
Fong, Fission yeast Pcp1 links polo kinase-mediated mitotic entry to gamma-tubulin-dependent spindle formation. 2010, Pubmed
Franckhauser, Distinct pools of cdc25C are phosphorylated on specific TP sites and differentially localized in human mitotic cells. 2010, Pubmed
Fry, C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. 1998, Pubmed
Fu, Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment. 2010, Pubmed , Xenbase
Fu, Structured illumination of the interface between centriole and peri-centriolar material. 2012, Pubmed
Fukasawa, P53, cyclin-dependent kinase and abnormal amplification of centrosomes. 2008, Pubmed
Furge, Byr4 and Cdc16 form a two-component GTPase-activating protein for the Spg1 GTPase that controls septation in fission yeast. 1998, Pubmed
Gabrielli, Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells. 1996, Pubmed
Gavet, Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis. 2010, Pubmed
Geiser, The essential mitotic target of calmodulin is the 110-kilodalton component of the spindle pole body in Saccharomyces cerevisiae. 1993, Pubmed
Geissler, The spindle pole body component Spc98p interacts with the gamma-tubulin-like Tub4p of Saccharomyces cerevisiae at the sites of microtubule attachment. 1996, Pubmed
George, Regulation of cell cycle and stress responses to hydrostatic pressure in fission yeast. 2007, Pubmed
Geymonat, In vitro regulation of budding yeast Bfa1/Bub2 GAP activity by Cdc5. 2003, Pubmed
Giansanti, Drosophila SPD-2 is an essential centriole component required for PCM recruitment and astral-microtubule nucleation. 2008, Pubmed
Giet, Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. 2002, Pubmed , Xenbase
Glover, Polo kinase and progression through M phase in Drosophila: a perspective from the spindle poles. 2005, Pubmed
Goetz, The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis. 2012, Pubmed
Gopalakrishnan, Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. 2011, Pubmed
Gopalakrishnan, Tubulin nucleotide status controls Sas-4-dependent pericentriolar material recruitment. 2012, Pubmed
Goshima, Genes required for mitotic spindle assembly in Drosophila S2 cells. 2007, Pubmed
Grallert, Removal of centrosomal PP1 by NIMA kinase unlocks the MPF feedback loop to promote mitotic commitment in S. pombe. 2013, Pubmed
Grallert, Recruitment of NIMA kinase shows that maturation of the S. pombe spindle-pole body occurs over consecutive cell cycles and reveals a role for NIMA in modulating SIN activity. 2004, Pubmed
Grallert, Centrosomal MPF triggers the mitotic and morphogenetic switches of fission yeast. 2013, Pubmed
Graser, Cep164, a novel centriole appendage protein required for primary cilium formation. 2007, Pubmed
Griffith, Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. 2008, Pubmed
Gruber, MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway. 2011, Pubmed
Gruneberg, Nud1p links astral microtubule organization and the control of exit from mitosis. 2000, Pubmed
Guderian, Plk4 trans-autophosphorylation regulates centriole number by controlling betaTrCP-mediated degradation. 2010, Pubmed
Guichard, Procentriole assembly revealed by cryo-electron tomography. 2010, Pubmed
Guichard, Cartwheel architecture of Trichonympha basal body. 2012, Pubmed
Habedanck, The Polo kinase Plk4 functions in centriole duplication. 2005, Pubmed
Hachet, Centrosomes promote timely mitotic entry in C. elegans embryos. 2007, Pubmed
Haren, Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components. 2009, Pubmed
Hartmuth, Fission yeast Tor1 functions as part of TORC1 to control mitotic entry through the stress MAPK pathway following nutrient stress. 2009, Pubmed
Hatano, The interrelationship between APC/C and Plk1 activities in centriole disengagement. 2012, Pubmed
Hatch, Cep152 interacts with Plk4 and is required for centriole duplication. 2010, Pubmed , Xenbase
Hatzopoulos, Structural analysis of the G-box domain of the microcephaly protein CPAP suggests a role in centriole architecture. 2013, Pubmed
Heath, Variant mitoses in lower eukaryotes: indicators of the evolution of mitosis. 1980, Pubmed
Heil-Chapdelaine, The cortical protein Num1p is essential for dynein-dependent interactions of microtubules with the cortex. 2000, Pubmed
Helps, NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1. 2000, Pubmed
Hemerly, Orc1 controls centriole and centrosome copy number in human cells. 2009, Pubmed
Hergovich, NDR kinases regulate essential cell processes from yeast to humans. 2006, Pubmed
Hilbert, Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry. 2013, Pubmed
Hinchcliffe, Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts. 1999, Pubmed , Xenbase
Hiraki, Bld10p constitutes the cartwheel-spoke tip and stabilizes the 9-fold symmetry of the centriole. 2007, Pubmed
Hoffmann, Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis. 1993, Pubmed , Xenbase
Holland, Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability. 2010, Pubmed
Holland, The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle. 2012, Pubmed
Hsu, Functional characterization of the microtubule-binding and -destabilizing domains of CPAP and d-SAS-4. 2008, Pubmed
Hu, Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints. 2001, Pubmed
Hudson, stf1: non-wee mutations epistatic to cdc25 in the fission yeast Schizosaccharomyces pombe. 1990, Pubmed
Hálová, Aurora promotes cell division during recovery from TOR-mediated cell cycle arrest by driving spindle pole body recruitment of Polo. 2011, Pubmed , Xenbase
Inanç, Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells. 2013, Pubmed
Ishikawa, Ciliogenesis: building the cell's antenna. 2011, Pubmed
Izumi, Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase. 1993, Pubmed , Xenbase
Izumi, Phosphorylation and activation of the Xenopus Cdc25 phosphatase in the absence of Cdc2 and Cdk2 kinase activity. 1995, Pubmed , Xenbase
Jackman, Active cyclin B1-Cdk1 first appears on centrosomes in prophase. 2003, Pubmed
Januschke, Drosophila neuroblasts retain the daughter centrosome. 2011, Pubmed
Januschke, Centrobin controls mother-daughter centriole asymmetry in Drosophila neuroblasts. 2013, Pubmed
Jaspersen, Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p. 2002, Pubmed
Jeffers, Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization. 2008, Pubmed
Jerka-Dziadosz, Basal body duplication in Paramecium: the key role of Bld10 in assembly and stability of the cartwheel. 2010, Pubmed
Joo, CCDC41 is required for ciliary vesicle docking to the mother centriole. 2013, Pubmed
Juanes, Spindle pole body history intrinsically links pole identity with asymmetric fate in budding yeast. 2013, Pubmed
Kapoor, Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. 2000, Pubmed , Xenbase
Karaiskou, Polo-like kinase confers MPF autoamplification competence to growing Xenopus oocytes. 2004, Pubmed , Xenbase
Karaïskou, Phosphatase 2A and polo kinase, two antagonistic regulators of cdc25 activation and MPF auto-amplification. 1999, Pubmed , Xenbase
Kashina, A bipolar kinesin. 1996, Pubmed
Kemp, Centrosome maturation and duplication in C. elegans require the coiled-coil protein SPD-2. 2004, Pubmed , Xenbase
Kiger, Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue. 2001, Pubmed
Kilmartin, Spc110p: assembly properties and role in the connection of nuclear microtubules to the yeast spindle pole body. 1996, Pubmed
Kilmartin, Lessons from yeast: the spindle pole body and the centrosome. 2014, Pubmed
Kilmartin, A spacer protein in the Saccharomyces cerevisiae spindle poly body whose transcript is cell cycle-regulated. 1993, Pubmed
Kilmartin, Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication. 2003, Pubmed
Kim, Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry. 2011, Pubmed , Xenbase
Kinoshita, Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis. 2005, Pubmed , Xenbase
Kirkham, SAS-4 is a C. elegans centriolar protein that controls centrosome size. 2003, Pubmed
Kitagawa, PP2A phosphatase acts upon SAS-5 to ensure centriole formation in C. elegans embryos. 2011, Pubmed
Kitagawa, Structural basis of the 9-fold symmetry of centrioles. 2011, Pubmed
Kitagawa, Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL. 2011, Pubmed
Kitagawa, Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos. 2009, Pubmed
Kleylein-Sohn, Plk4-induced centriole biogenesis in human cells. 2007, Pubmed
Knop, The spindle pole body component Spc97p interacts with the gamma-tubulin of Saccharomyces cerevisiae and functions in microtubule organization and spindle pole body duplication. 1997, Pubmed
Knop, Receptors determine the cellular localization of a gamma-tubulin complex and thereby the site of microtubule formation. 1998, Pubmed
Knop, Spc98p and Spc97p of the yeast gamma-tubulin complex mediate binding to the spindle pole body via their interaction with Spc110p. 1997, Pubmed
Kobayashi, Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis. 2011, Pubmed
Kohlmaier, Overly long centrioles and defective cell division upon excess of the SAS-4-related protein CPAP. 2009, Pubmed
Kollman, Microtubule nucleating gamma-TuSC assembles structures with 13-fold microtubule-like symmetry. 2010, Pubmed
Kollman, The structure of the gamma-tubulin small complex: implications of its architecture and flexibility for microtubule nucleation. 2008, Pubmed
Kollman, Microtubule nucleation by γ-tubulin complexes. 2011, Pubmed
Korzeniewski, Daughter centriole elongation is controlled by proteolysis. 2010, Pubmed
Kouprina, The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein. 2005, Pubmed
Kovelman, Stockpiling of Cdc25 during a DNA replication checkpoint arrest in Schizosaccharomyces pombe. 1996, Pubmed
Kumagai, Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts. 1996, Pubmed , Xenbase
Lacey, Cyclin-dependent kinase control of centrosome duplication. 1999, Pubmed , Xenbase
Lau, STED microscopy with optimized labeling density reveals 9-fold arrangement of a centriole protein. 2012, Pubmed
Lawo, Subdiffraction imaging of centrosomes reveals higher-order organizational features of pericentriolar material. 2012, Pubmed
Lee, Positioning of the mitotic spindle by a cortical-microtubule capture mechanism. 2000, Pubmed
Lee, Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway. 2012, Pubmed
Lee, PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis. 2011, Pubmed
Lee, Separase-dependent cleavage of pericentrin B is necessary and sufficient for centriole disengagement during mitosis. 2012, Pubmed
Leidel, SAS-4 is essential for centrosome duplication in C elegans and is recruited to daughter centrioles once per cell cycle. 2003, Pubmed
Leidel, SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells. 2005, Pubmed
Lerit, PLP inhibits the activity of interphase centrosomes to ensure their proper segregation in stem cells. 2013, Pubmed
Lettman, Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly. 2013, Pubmed
Leung, The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization. 2002, Pubmed
Li, USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. 2013, Pubmed
Li, Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors. 2011, Pubmed
Li, Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication. 2006, Pubmed
Liang, BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice. 2010, Pubmed
Lin, Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly. 2013, Pubmed
Lin, CEP120 interacts with CPAP and positively regulates centriole elongation. 2013, Pubmed
Lin, Cell-cycle dependent phosphorylation of yeast pericentrin regulates γ-TuSC-mediated microtubule nucleation. 2014, Pubmed
Lin, BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. 2005, Pubmed
Lindqvist, The decision to enter mitosis: feedback and redundancy in the mitotic entry network. 2009, Pubmed
Lindqvist, Cdc25B cooperates with Cdc25A to induce mitosis but has a unique role in activating cyclin B1-Cdk1 at the centrosome. 2005, Pubmed
Lizarraga, Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. 2010, Pubmed
Loncarek, Centriole reduplication during prolonged interphase requires procentriole maturation governed by Plk1. 2010, Pubmed
Lu, Geminin is partially localized to the centrosome and plays a role in proper centrosome duplication. 2009, Pubmed
MacIver, Physical and functional interactions between polo kinase and the spindle pole component Cut12 regulate mitotic commitment in S. pombe. 2003, Pubmed
Macůrek, Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. 2008, Pubmed
Maekawa, The yeast centrosome translates the positional information of the anaphase spindle into a cell cycle signal. 2007, Pubmed
Mahen, Continuous polo-like kinase 1 activity regulates diffusion to maintain centrosome self-organization during mitosis. 2011, Pubmed
Mahjoub, Cep120 is asymmetrically localized to the daughter centriole and is essential for centriole assembly. 2010, Pubmed
Mahjoub, The FA2 gene of Chlamydomonas encodes a NIMA family kinase with roles in cell cycle progression and microtubule severing during deflagellation. 2002, Pubmed
Mardin, Plk1 controls the Nek2A-PP1γ antagonism in centrosome disjunction. 2011, Pubmed
Mardin, Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction. 2010, Pubmed
Matsumoto, Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells. 1999, Pubmed
Matsuo, Kendrin is a novel substrate for separase involved in the licensing of centriole duplication. 2012, Pubmed , Xenbase
Matsuo, Involvement of a centrosomal protein kendrin in the maintenance of centrosome cohesion by modulating Nek2A kinase activity. 2010, Pubmed
Matsuyama, Nuclear Chk1 prevents premature mitotic entry. 2011, Pubmed
Mayor, The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion. 2000, Pubmed
McMillan, The JNM1 gene in the yeast Saccharomyces cerevisiae is required for nuclear migration and spindle orientation during the mitotic cell cycle. 1994, Pubmed
Megraw, The centrosomin protein is required for centrosome assembly and function during cleavage in Drosophila. 1999, Pubmed
Meitinger, The power of MEN in cytokinesis. 2012, Pubmed
Mennella, Subdiffraction-resolution fluorescence microscopy reveals a domain of the centrosome critical for pericentriolar material organization. 2012, Pubmed
Meraldi, Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. 1999, Pubmed
Miller, Kar9p is a novel cortical protein required for cytoplasmic microtubule orientation in yeast. 1998, Pubmed
Miller, The kinesin-related proteins, Kip2p and Kip3p, function differently in nuclear migration in yeast. 1998, Pubmed
Mori, NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. 2007, Pubmed
Moritz, Microtubule nucleation by gamma-tubulin-containing rings in the centrosome. 1995, Pubmed
Morrison, Asymmetric and symmetric stem-cell divisions in development and cancer. 2006, Pubmed
Mottier-Pavie, Drosophila bld10 is a centriolar protein that regulates centriole, basal body, and motile cilium assembly. 2009, Pubmed
Mulvihill, Plo1 kinase recruitment to the spindle pole body and its role in cell division in Schizosaccharomyces pombe. 1999, Pubmed
Nakamura, SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress. 2013, Pubmed
Nakazawa, SAS-6 is a cartwheel protein that establishes the 9-fold symmetry of the centriole. 2007, Pubmed
Noatynska, Mitotic spindle (DIS)orientation and DISease: cause or consequence? 2012, Pubmed
Novak, Asterless licenses daughter centrioles to duplicate for the first time in Drosophila embryos. 2014, Pubmed
Nurse, Universal control mechanism regulating onset of M-phase. 1990, Pubmed
O'Connell, The C. elegans zyg-1 gene encodes a regulator of centrosome duplication with distinct maternal and paternal roles in the embryo. 2001, Pubmed
Ohkura, The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells. 1995, Pubmed
Okuda, Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. 2000, Pubmed
Oliveira, Cohesin cleavage is insufficient for centriole disengagement in Drosophila. 2013, Pubmed
Pan, An aurora kinase is essential for flagellar disassembly in Chlamydomonas. 2004, Pubmed
Parker, Centrioles are freed from cilia by severing prior to mitosis. 2010, Pubmed
Pedersen, Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling. 2008, Pubmed
Peel, The C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels. 2012, Pubmed
Pelletier, The Caenorhabditis elegans centrosomal protein SPD-2 is required for both pericentriolar material recruitment and centriole duplication. 2004, Pubmed
Pelletier, Centriole assembly in Caenorhabditis elegans. 2006, Pubmed
Peng, BRIT1/MCPH1 links chromatin remodelling to DNA damage response. 2009, Pubmed
Pereira, Kin4 kinase delays mitotic exit in response to spindle alignment defects. 2005, Pubmed
Pereira, Modes of spindle pole body inheritance and segregation of the Bfa1p-Bub2p checkpoint protein complex. 2001, Pubmed
Pereira, The role of the yeast spindle pole body and the mammalian centrosome in regulating late mitotic events. 2001, Pubmed
Pereira, The Bub2p spindle checkpoint links nuclear migration with mitotic exit. 2000, Pubmed
Petersen, TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases. 2007, Pubmed
Petersen, Polo kinase links the stress pathway to cell cycle control and tip growth in fission yeast. 2005, Pubmed
Prosser, Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification. 2012, Pubmed
Pugacheva, The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome. 2005, Pubmed
Pugacheva, HEF1-dependent Aurora A activation induces disassembly of the primary cilium. 2007, Pubmed
Puklowski, The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication. 2011, Pubmed
Pulvers, Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline. 2010, Pubmed
Pérez-Mongiovi, Nuclei and microtubule asters stimulate maturation/M phase promoting factor (MPF) activation in Xenopus eggs and egg cytoplasmic extracts. 2000, Pubmed , Xenbase
Qiao, SAS-6 coiled-coil structure and interaction with SAS-5 suggest a regulatory mechanism in C. elegans centriole assembly. 2012, Pubmed
Quarmby, Cellular Samurai: katanin and the severing of microtubules. 2000, Pubmed
Raff, Nuclear and cytoplasmic mitotic cycles continue in Drosophila embryos in which DNA synthesis is inhibited with aphidicolin. 1988, Pubmed
Rai, BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. 2006, Pubmed
Rai, Differential regulation of centrosome integrity by DNA damage response proteins. 2008, Pubmed
Rebollo, Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells. 2007, Pubmed
Riparbelli, Assembly and persistence of primary cilia in dividing Drosophila spermatocytes. 2012, Pubmed
Rodrigues-Martins, Revisiting the role of the mother centriole in centriole biogenesis. 2007, Pubmed
Rodrigues-Martins, DSAS-6 organizes a tube-like centriole precursor, and its absence suggests modularity in centriole assembly. 2007, Pubmed
Rogers, The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication. 2009, Pubmed
Roque, Drosophila Cep135/Bld10 maintains proper centriole structure but is dispensable for cartwheel formation. 2012, Pubmed
Rose, KAR1, a gene required for function of both intranuclear and extranuclear microtubules in yeast. 1987, Pubmed
Salisbury, A mechanistic view on the evolutionary origin for centrin-based control of centriole duplication. 2007, Pubmed
Samejima, Two distinct regions of Mto1 are required for normal microtubule nucleation and efficient association with the gamma-tubulin complex in vivo. 2008, Pubmed
Saunders, The Drosophila gene abnormal spindle encodes a novel microtubule-associated protein that associates with the polar regions of the mitotic spindle. 1997, Pubmed
Schaerer, Cnm67p is a spacer protein of the Saccharomyces cerevisiae spindle pole body outer plaque. 2001, Pubmed
Schmidt, Control of centriole length by CPAP and CP110. 2009, Pubmed
Schuldt, Cytoskeleton: SAS-6 turns a cartwheel trick. 2011, Pubmed
Schöckel, Cleavage of cohesin rings coordinates the separation of centrioles and chromatids. 2011, Pubmed , Xenbase
Seki, Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. 2008, Pubmed , Xenbase
Shaw, Astral microtubule dynamics in yeast: a microtubule-based searching mechanism for spindle orientation and nuclear migration into the bud. 1997, Pubmed
Sillibourne, Assessing the localization of centrosomal proteins by PALM/STORM nanoscopy. 2011, Pubmed
Sillibourne, Autophosphorylation of polo-like kinase 4 and its role in centriole duplication. 2010, Pubmed
Simanis, Events at the end of mitosis in the budding and fission yeasts. 2003, Pubmed
Singh, The centriolar protein Bld10/Cep135 is required to establish centrosome asymmetry in Drosophila neuroblasts. 2014, Pubmed
Singla, Ofd1, a human disease gene, regulates the length and distal structure of centrioles. 2010, Pubmed
Sir, A primary microcephaly protein complex forms a ring around parental centrioles. 2011, Pubmed
Slevin, The structure of the plk4 cryptic polo box reveals two tandem polo boxes required for centriole duplication. 2012, Pubmed
Song, Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. 2011, Pubmed
Sonnen, Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication. 2013, Pubmed
Sonnen, 3D-structured illumination microscopy provides novel insight into architecture of human centrosomes. 2012, Pubmed
Spang, The calcium-binding protein cell division cycle 31 of Saccharomyces cerevisiae is a component of the half bridge of the spindle pole body. 1993, Pubmed
Spang, The spacer protein Spc110p targets calmodulin to the central plaque of the yeast spindle pole body. 1996, Pubmed
Spang, The Cdc31p-binding protein Kar1p is a component of the half bridge of the yeast spindle pole body. 1995, Pubmed
Spektor, Cep97 and CP110 suppress a cilia assembly program. 2007, Pubmed
Stegmeier, Closing mitosis: the functions of the Cdc14 phosphatase and its regulation. 2004, Pubmed
Stevens, DSas-6 and Ana2 coassemble into tubules to promote centriole duplication and engagement. 2010, Pubmed
Stirling, Interaction with calmodulin is required for the function of Spc110p, an essential component of the yeast spindle pole body. 1994, Pubmed
Strausfeld, Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis. 1994, Pubmed
Strnad, Regulated HsSAS-6 levels ensure formation of a single procentriole per centriole during the centrosome duplication cycle. 2007, Pubmed
Sundberg, A mutational analysis identifies three functional regions of the spindle pole component Spc110p in Saccharomyces cerevisiae. 1997, Pubmed
Tachibana, Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects. 2005, Pubmed
Tallada, Suppression of the Schizosaccharomyces pombe cut12.1 cell-cycle defect by mutations in cdc25 and genes involved in transcriptional and translational control. 2007, Pubmed
Tallada, The S. pombe mitotic regulator Cut12 promotes spindle pole body activation and integration into the nuclear envelope. 2009, Pubmed
Tanaka, The role of Plo1 kinase in mitotic commitment and septation in Schizosaccharomyces pombe. 2001, Pubmed
Tang, CPAP is a cell-cycle regulated protein that controls centriole length. 2009, Pubmed
Tang, The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation. 2011, Pubmed
Tanos, Centriole distal appendages promote membrane docking, leading to cilia initiation. 2013, Pubmed
Teixidó-Travesa, The where, when and how of microtubule nucleation - one ring to rule them all. 2012, Pubmed
Terada, Interaction of Aurora-A and centrosomin at the microtubule-nucleating site in Drosophila and mammalian cells. 2003, Pubmed , Xenbase
Thornton, Primary microcephaly: do all roads lead to Rome? 2009, Pubmed
Tibelius, Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1. 2009, Pubmed
Tokuyama, Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication. 2001, Pubmed
Trimborn, Establishment of a mouse model with misregulated chromosome condensation due to defective Mcph1 function. 2010, Pubmed
Tsang, CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease. 2008, Pubmed
Tsou, Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells. 2009, Pubmed
Tsou, Mechanism limiting centrosome duplication to once per cell cycle. 2006, Pubmed , Xenbase
Tulina, Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling. 2001, Pubmed
Varmark, Asterless is a centriolar protein required for centrosome function and embryo development in Drosophila. 2007, Pubmed
Visintin, The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. 1998, Pubmed
Vulprecht, STIL is required for centriole duplication in human cells. 2012, Pubmed
Wang, PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry. 2013, Pubmed
Wang, The conversion of centrioles to centrosomes: essential coupling of duplication with segregation. 2011, Pubmed
Wang, Asymmetric centrosome inheritance maintains neural progenitors in the neocortex. 2009, Pubmed
Wang, Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex. 2010, Pubmed
Wang, sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1. 2008, Pubmed
Wood, Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair. 2008, Pubmed
Xu, Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. 2004, Pubmed
Yamashita, Asymmetric inheritance of mother versus daughter centrosome in stem cell division. 2007, Pubmed
Yang, Rootletin interacts with C-Nap1 and may function as a physical linker between the pair of centrioles/basal bodies in cells. 2006, Pubmed
Yeh, Dynamic positioning of mitotic spindles in yeast: role of microtubule motors and cortical determinants. 2000, Pubmed
Yeh, Spindle dynamics and cell cycle regulation of dynein in the budding yeast, Saccharomyces cerevisiae. 1995, Pubmed
Yin, Myosin V orientates the mitotic spindle in yeast. 2000, Pubmed
Zhang, Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome. 2009, Pubmed
Zhang, Proper recruitment of gamma-tubulin and D-TACC/Msps to embryonic Drosophila centrosomes requires Centrosomin Motif 1. 2007, Pubmed
van Breugel, Structures of SAS-6 suggest its organization in centrioles. 2011, Pubmed
van der Voet, NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha. 2009, Pubmed