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Semin Cell Dev Biol 2016 Mar 01;51:64-72. doi: 10.1016/j.semcdb.2016.02.003.
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Using Xenopus laevis retinal and spinal neurons to study mechanisms of axon guidance in vivo and in vitro.

Erdogan B , Ebbert PT , Lowery LA .

The intricate and precise establishment of neuronal connections in the developing nervous system relies on accurate navigation of growing axons. Since Ramón y Cajal's discovery of the growth cone, the phenomenon of axon guidance has been revealed as a coordinated operation of guidance molecules, receptors, secondary messengers, and responses driven by the dynamic cytoskeleton within the growth cone. With the advent of new and accelerating techniques, Xenopus laevis emerged as a robust model to investigate neuronal circuit formation during development. We present here the advantages of the Xenopus nervous system to our growing understanding of axon guidance.

PubMed ID: 26853934
PMC ID: PMC4798887
Article link: Semin Cell Dev Biol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: bdnf lmna ntn1

References [+] :
Akhmanova, Tracking the ends: a dynamic protein network controls the fate of microtubule tips. 2008, Pubmed