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Curr Top Dev Biol 2016 Jan 01;117:359-76. doi: 10.1016/bs.ctdb.2015.11.036.
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Mechanotransduction During Vertebrate Neurulation.

Vertebrate neural tube formation is a complex morphogenetic process, which involves hundreds of genes dynamically coordinating various behaviors in different cell populations of neural tissue. The challenge remains to determine the relative contributions of physical forces and biochemical signaling events to neural tube closure and accompanying cell fate specification. Planar cell polarity (PCP) molecules are prime candidate factors for the production of actomyosin-dependent mechanical signals necessary for morphogenesis. Conversely, physical forces may contribute to the polarized distribution of PCP proteins. Understanding mechanosensory and mechanotransducing properties of diverse molecules should help define the direction and amplitude of physical stresses that are critical for neurulation.

PubMed ID: 26969989
Article link: Curr Top Dev Biol
Grant support: [+]

Species referenced: Xenopus
Genes referenced: actr2 actr3 celsr1 cfl1 ctnnd1 daam1 fmn1 fuz fzd8 prickle1 rab11a rock1 shroom3 sox3 tbxt tjp1 twist1 vangl2 wdr1 wnt1 yap1 ybx3