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Genesis 2017 Jan 01;551-2:. doi: 10.1002/dvg.23015.
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Transcriptional dynamics of tail regeneration in Xenopus tropicalis.

Chang J , Baker J , Wills A .

In contrast to humans, many amphibians are able to rapidly and completely regenerate complex tissues, including entire appendages. Following tail amputation, Xenopus tropicalis tadpoles quickly regenerate muscle, spinal cord, cartilage, vasculature and skin, all properly patterned in three dimensions. To better understand the molecular basis of this regenerative competence, we performed a transcriptional analysis of the first 72 h of tail regeneration using RNA-Seq. Our analysis refines the windows during which many key biological signaling processes act in regeneration, including embryonic patterning signals, immune responses, bioelectrical signaling and apoptosis. Our work provides a deep database for researchers interested in appendage regeneration, and points to new avenues for further study.

PubMed ID: 28095651
Article link: Genesis

Species referenced: Xenopus tropicalis
Genes referenced: hpse map1a map1b odad2 racgap1 spi1 spib

GEO Series: GSE88975: Xenbase,  NCBI

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