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Biol Open 2017 Jun 15;66:862-871. doi: 10.1242/bio.023739.
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The role of nitric oxide during embryonic epidermis development of Xenopus laevis.

Tomankova S , Abaffy P , Sindelka R .

Nitric oxide (NO) is a potent radical molecule that participates in various biological processes such as vasodilation, cell proliferation, immune response and neurotransmission. NO mainly activates soluble guanylate cyclase, leading to cGMP production and activation of protein kinase G and its downstream targets. Here we report the essential role of NO during embryonic epidermis development. Xenopus embryonic epidermis has become a useful model reflecting human epithelial tissue composition. The developing epidermis of Xenopus laevis is formed from specialized ionocytes, multi-ciliated, goblet and small secretory cells. We found that NO is mainly produced in multi-ciliated cells and ionocytes. Production of NO during early developmental stages is required for formation of multi-ciliated cells, ionocytes and small secretory cells by regulation of epidermal-specific gene expression. The data from this research indicate a novel role of NO during development, which supports recent findings of NO production in human mucociliary and epithelium development.

PubMed ID: 28483981
PMC ID: PMC5483018
Article link: Biol Open

Species referenced: Xenopus laevis
Genes referenced: actb ctrl foxa1 foxi1 mos nos1 nos3 notch1 otogl2 prkg1 tuba4b tubg1
Antibodies: Fluro-phalloidin Ab2 Seratonin Ab2 Tuba4b Ab20 Tubg1 Ab4
Morpholinos: nos1 MO1 nos3 MO1 notch1 MO1 prkg1 MO1

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References [+] :
Albina, Nitric oxide-mediated apoptosis in murine peritoneal macrophages. 1993, Pubmed