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Gene Expr Patterns 2018 Dec 01;30:64-70. doi: 10.1016/j.gep.2018.10.001.
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Expression of trpv channels during Xenopus laevis embryogenesis.

Dong C , Paudel S , Amoh NY , Saha MS .

Transient receptor potential (TRP) cation channel genes code for an extensive family of conserved proteins responsible for a variety of physiological processes, including sensory perception, ion homeostasis, and chemical signal transduction. The TRP superfamily consists of seven subgroups, one of which is the transient receptor potential vanilloid (trpv) channel family. While trpv channels are relatively well studied in adult vertebrate organisms given their role in functions such as nociception, thermoregulation, and osmotic regulation in mature tissues and organ systems, relatively little is known regarding their function during embryonic development. Although there are some reports of the expression of specific trpv channels at particular stages in various organisms, there is currently no comprehensive analysis of trpv channels during embryogenesis. Here, performing in situ hybridization, we examined the spatiotemporal expression of trpv channel mRNA during early Xenopus laevis embryogenesis. Trpv channels exhibited unique patterns of embryonic expression at distinct locations including the trigeminal ganglia, spinal cord, cement gland, otic vesicle, optic vesicle, nasal placode, notochord, tailbud, proctodeum, branchial arches, epithelium, somite and the animal pole during early development. We have also observed the colocalization of trpv channels at the animal pole (trpv 2/4), trigeminal ganglia (trpv 1/2), and epithelium (trpv 5/6). These localization patterns suggest that trpv channels may play diverse roles during early embryonic development.

PubMed ID: 30326274
PMC ID: PMC6319392
Article link: Gene Expr Patterns
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: trpv1 trpv2 trpv4 trpv5 trpv6
GO keywords: embryo development [+]

Article Images: [+] show captions
References [+] :
Antin, Gallus expression in situ hybridization analysis: a chicken embryo gene expression database. 2007, Pubmed