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Dev Growth Differ 2019 Jun 01;615:327-336. doi: 10.1111/dgd.12609.
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Mechanistic insights from the LHX1-driven molecular network in building the embryonic head.

McMahon R , Sibbritt T , Salehin N , Osteil P , Tam PPL .

Development of an embryo is driven by a series of molecular instructions that control the differentiation of tissue precursor cells and shape the tissues into major body parts. LIM homeobox 1 (LHX1) is a transcription factor that plays a major role in the development of the embryonic head of the mouse. Loss of LHX1 function disrupts the morphogenetic movement of head tissue precursors and impacts on the function of molecular factors in modulating the activity of the WNT signaling pathway. LHX1 acts with a transcription factor complex to regulate the transcription of target genes in multiple phases of development and in a range of embryonic tissues of the mouse and Xenopus. Determining the interacting factors and transcriptional targets of LHX1 will be key to unraveling the ensemble of factors involved in head development and building a head gene regulatory network.

PubMed ID: 31111476
Article link: Dev Growth Differ
Grant support: [+]

Species referenced: Xenopus
Genes referenced: bcl2l1 celsr1 col2a1 dkk1 eomes epha7 ephb1 foxp1 frzb gsc hesx1 lamc1 lhx1 otx2 pcdh7 pcdh8 sox3 twist1 wnt1