Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Life Sci Alliance 2021 Jul 05;48:. doi: 10.26508/lsa.202101105.
Show Gene links Show Anatomy links

Axon terminals control endolysosome diffusion to support synaptic remodelling.

Terni B , Llobet A .

Endolysosomes are acidic organelles formed by the fusion of endosomes with lysosomes. In the presynaptic compartment they contribute to protein homeostasis, the maintenance of vesicle pools and synaptic stability. Here, we evaluated the mobility of endolysosomes found in axon terminals of olfactory sensory neurons of Xenopus tropicalis tadpoles. F-actin restricts the motion of these presynaptic acidic organelles which is characterized by a diffusion coefficient of 6.7 × 10-3 μm2·s-1 Local injection of secreted protein acidic and rich in cysteine (SPARC) in the glomerular layer of the olfactory bulb disrupts the structure of synaptic F-actin patches and increases the presence and mobility of endolysosomal organelles found in axon terminals. The increased motion of endolysosomes is localized to the presynaptic compartment and does not promote their access to axonal regions for retrograde transportation to the cell body. Local activation of synaptic degradation mechanisms mediated by SPARC coincides with a loss of the ability of tadpoles to detect waterborne odorants. Together, these observations show that the diffusion of presynaptic endolysosomes increases during conditions of synaptic remodelling to support their local degradative activity.

PubMed ID: 34226200
PMC ID: PMC8321675
Article link: Life Sci Alliance

Species referenced: Xenopus tropicalis
Genes referenced: sparc
GO keywords: endolysosome [+]

Article Images: [+] show captions
References [+] :
Albrecht, Nanoscopic compartmentalization of membrane protein motion at the axon initial segment. 2016, Pubmed