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XB-ART-58497
Chem Biol Interact 2022 Jan 05;351:109671. doi: 10.1016/j.cbi.2021.109671.
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Evolution of aldehyde dehydrogenase genes and proteins in diploid and allotetraploid Xenopus frog species.

Holmes RS .


Abstract
At least 19 human aldehyde dehydrogenase (ALDH) genes and enzymes have been studied among vertebrate organisms. BLAT and BLAST analyses were undertaken of Xenopus tropicalis (western clawed frog) and Xenopus laevis (African clawed frog) genomes which are related diploid (N = 20) and allotetraploid (N = 36) species, respectively. The corresponding ALDH genes and proteins within these Xenopus genomes were identified and studied. Evidence is presented for tetraploid copies of 10 Xenopus laevis ALDH genes, whereas another 7 identified ALDH genes were diploid in nature. Xenopus laevis and Xenopus tropicalis ALDH amino acid sequences were highly homologous with the human enzymes, with the exception of the mitochondrial signal peptide sequences. Amino acids performing catalytic and structural roles were conserved and identified based on previous reports of 3D structures for the corresponding mammalian enzymes.

PubMed ID: 34599912
Article link: Chem Biol Interact


Species referenced: Xenopus tropicalis Xenopus laevis
Genes referenced: aldh16a1 aldh18a1 aldh1a1 aldh1a2 aldh1a3 aldh1b1 aldh1l1 aldh1l2 aldh2 aldh3a2 aldh3b1 aldh4a1 aldh5a1 aldh6a1 aldh7a1 aldh8a1 aldh9a1