Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Cells 2021 Jul 30;108:. doi: 10.3390/cells10081937.
Show Gene links Show Anatomy links

ZC3HC1 Is a Novel Inherent Component of the Nuclear Basket, Resident in a State of Reciprocal Dependence with TPR.

Gunkel P , Iino H , Krull S , Cordes VC .

The nuclear basket (NB) scaffold, a fibrillar structure anchored to the nuclear pore complex (NPC), is regarded as constructed of polypeptides of the coiled-coil dominated protein TPR to which other proteins can bind without contributing to the NB's structural integrity. Here we report vertebrate protein ZC3HC1 as a novel inherent constituent of the NB, common at the nuclear envelopes (NE) of proliferating and non-dividing, terminally differentiated cells of different morphogenetic origin. Formerly described as a protein of other functions, we instead present the NB component ZC3HC1 as a protein required for enabling distinct amounts of TPR to occur NB-appended, with such ZC3HC1-dependency applying to about half the total amount of TPR at the NEs of different somatic cell types. Furthermore, pointing to an NB structure more complex than previously anticipated, we discuss how ZC3HC1 and the ZC3HC1-dependent TPR polypeptides could enlarge the NB's functional repertoire.

PubMed ID: 34440706
Article link: Cells

Species referenced: Xenopus laevis
Genes referenced: ccnb1 cul1 lmnb2 mad1l1 mad2l1 mxd1 nbn nup107 nup153 nup62 nup98 nxf1 psmd6 skp1 tpr zc3hc1
GO keywords: nuclear envelope [+]

Article Images: [+] show captions
References [+] :
Adey, The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line. 2013, Pubmed