Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Int J Mol Sci 2022 May 17;2310:. doi: 10.3390/ijms23105627.
Show Gene links Show Anatomy links

The Cytoskeletal Protein Zyxin Inhibits Retinoic Acid Signaling by Destabilizing the Maternal mRNA of the RXRγ Nuclear Receptor.

Parshina EA , Orlov EE , Zaraisky AG , Martynova NY .

Zyxin is an LIM-domain-containing protein that regulates the assembly of F-actin filaments in cell contacts. Additionally, as a result of mechanical stress, Zyxin can enter nuclei and regulate gene expression. Previously, we found that Zyxin could affect mRNA stability of the maternally derived stemness factors of Pou5f3 family in Xenopus laevis embryos through binding to Y-box factor1. In the present work, we demonstrate that Zyxin can also affect mRNA stability of the maternally derived retinoid receptor Rxrγ through the same mechanism. Moreover, we confirmed the functional link between Zyxin and Rxrγ-dependent gene expression. As a result, Zyxin appears to play an essential role in the regulation of the retinoic acid signal pathway during early embryonic development. Besides, our research indicates that the mechanism based on the mRNA destabilization by Zyxin may take part in the control of the expression of a fairly wide range of maternal genes.

PubMed ID: 35628438
Article link: Int J Mol Sci
Grant support: [+]

Genes referenced: acss2.2 eef1a1 mrc1 odc1 pou5f3 rxrg zyx
GO keywords: retinoic acid binding [+]
Morpholinos: zyx MO1 zyx MO2

Article Images: [+] show captions
References [+] :
Allenby, Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. 1993, Pubmed