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XB-ART-6020
Biol Cell 2002 Sep 01;944-5:217-31. doi: 10.1016/s0248-4900(02)01195-4.
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Characterization of the poly(A) binding proteins expressed during oogenesis and early development of Xenopus laevis.

Cosson B , Couturier A , Le Guellec R , Moreau J , Chabelskaya S , Zhouravleva G , Philippe M .


Abstract
During vertebrate oogenesis and early embryogenesis, gene expression is governed mainly by translational control. The recruitment of Poly(A) Binding Protein (PABP) during poly(A) tail lengthening appears to be the key to translational activation during this period of development in Xenopus laevis. We showed that PABP1 and ePABP proteins are both present during oogenesis and early development. We selected ePABP as an eRF3 binding protein in a two-hybrid screening of a X. laevis cDNA library and demonstrated that this protein is associated with translational complexes. It can complement essential functions of the yeast homologue Pab1p. We discuss specific expression patterns of the finely tuned PABP1 and ePABP proteins.

PubMed ID: 12489691
Article link: Biol Cell


Species referenced: Xenopus laevis
Genes referenced: pabpc1 pabpc1l pabpc4