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Expert Opin Drug Discov 2024 Feb 01;192:173-187. doi: 10.1080/17460441.2023.2270902.
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Advancements in the use of xenopus oocytes for modelling neurological disease for novel drug discovery.

O'Connor EC , Kambara K , Bertrand D .

INTRODUCTION: Introduced about 50 years ago, the model of Xenopus oocytes for the expression of recombinant proteins has gained a broad spectrum of applications. The authors herein review the benefits brought from using this model system, with a focus on modeling neurological disease mechanisms and application to drug discovery. AREAS COVERED: Using multiple examples spanning from ligand gated ion channels to transporters, this review presents, in the light of the latest publications, the benefits offered from using Xenopus oocytes. Studies range from the characterization of gene mutations to the discovery of novel treatments for disorders of the central nervous system (CNS). EXPERT OPINION: Development of new drugs targeting CNS disorders has been marked by failures in the translation from preclinical to clinical studies. As progress in genetics and molecular biology highlights large functional differences arising from a single to a few amino acid exchanges, the need for drug screening and functional testing against human proteins is increasing. The use of Xenopus oocytes to enable precise modeling and characterization of clinically relevant genetic variants constitutes a powerful model system that can be used to inform various aspects of CNS drug discovery and development.

PubMed ID: 37850233
Article link: Expert Opin Drug Discov

Species referenced: Xenopus laevis
Genes referenced: aqp4 chrna4 gabarap grin1 grin2a hcn1 kcnj10 kcnma1 kcnt1 kcnt2 slc12a6 slc1a2
GO keywords: G-protein coupled receptor activity [+]

Disease Ontology terms: electroclinical syndrome [+]

Article Images: [+] show captions