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XB-ART-60536
Dev Cell 2009 Jul 01;171:9-26. doi: 10.1016/j.devcel.2009.06.016.
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Wnt/beta-catenin signaling: components, mechanisms, and diseases.

MacDonald BT , Tamai K , He X .


Abstract
Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator beta-catenin controls embryonic development and adult homeostasis. Here we review recent progress in this so-called canonical Wnt signaling pathway. We discuss Wnt ligands, agonists, and antagonists, and their interactions with Wnt receptors. We also dissect critical events that regulate beta-catenin stability, from Wnt receptors to the cytoplasmic beta-catenin destruction complex, and nuclear machinery that mediates beta-catenin-dependent transcription. Finally, we highlight some key aspects of Wnt/beta-catenin signaling in human diseases including congenital malformations, cancer, and osteoporosis, and discuss potential therapeutic implications.

PubMed ID: 19619488
PMC ID: PMC2861485
Article link: Dev Cell
Grant support: [+]

Species referenced: Xenopus tropicalis Xenopus laevis
Genes referenced: apc axin1 cer1 ctnnb1 dkk1 fzd1 fzd4 gsk3a gsk3b lrp5 lrp6 macf1 ndp npy4r ptpa rspo1 wls wnt1 wnt3a
GO keywords: receptor-mediated endocytosis [+]

Disease Ontology terms: tetraamelia syndrome
OMIMs: COLORECTAL CANCER; CRC [+]

Article Images: [+] show captions
References [+] :
Adaimy, Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia. 2007, Pubmed