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Int J Mol Sci 2024 Feb 19;254:. doi: 10.3390/ijms25042412.
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The Molecular Mechanism of Body Axis Induction in Lampreys May Differ from That in Amphibians.

Ermakova GV , Kucheryavyy AV , Zaraisky AG , Bayramov AV .

Lamprey homologues of the classic embryonic inducer Noggin are similar in expression pattern and functional properties to Noggin homologues of jawed vertebrates. All noggin genes of vertebrates apparently originated from a single ancestral gene as a result of genome duplications. nogginA, nogginB and nogginC of lampreys, like noggin1 and noggin2 of gnathostomes, demonstrate the ability to induce complete secondary axes with forebrain and eye structures when overexpressed in Xenopus laevis embryos. According to current views, this finding indicates the ability of lamprey Noggin proteins to suppress the activity of the BMP, Nodal/Activin and Wnt/beta-catenin signaling pathways, as shown for Noggin proteins of gnathostomes. In this work, by analogy with experiments in Xenopus embryos, we attempted to induce secondary axes in the European river lamprey Lampetra fluviatilis by injecting noggin mRNAs into lamprey eggs in vivo. Surprisingly, unlike what occurs in amphibians, secondary axis induction in the lampreys either by noggin mRNAs or by chordin and cerberus mRNAs, the inductive properties of which have been described, was not observed. Only wnt8a mRNA demonstrated the ability to induce secondary axes in the lampreys. Such results may indicate that the mechanism of axial specification in lampreys, which represent jawless vertebrates, may differ in detail from that in the jawed clade.

PubMed ID: 38397089
PMC ID: PMC10889193
Article link: Int J Mol Sci
Grant support: [+]

Species referenced: Xenopus Xenopus tropicalis Xenopus laevis
Genes referenced: cer1 chrd myc nog nog2 shh wnt8a

Article Images: [+] show captions
References [+] :
Angerer, The evolution of nervous system patterning: insights from sea urchin development. 2011, Pubmed