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J Physiol 2002 Jul 01;542Pt 1:119-30.
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KCNE4 is an inhibitory subunit to the KCNQ1 channel.

Grunnet M , Jespersen T , Rasmussen HB , Ljungstrøm T , Jorgensen NK , Olesen SP , Klaerke DA .

KCNE4 is a membrane protein belonging to a family of single transmembrane domain proteins known to have dramatic effect on the gating of certain potassium channels. However, no functional role of KCNE4 has been suggested so far. In the present paper we demonstrate that KCNE4 is an inhibitory subunit to KCNQ1 channels. Co-expression of KCNQ1 and KCNE4 in Xenopus oocytes completely inhibited the KCNQ1 current. This was reproduced in mammalian CHO-K1 cells. Experiments with delayed expression of mRNA coding for KCNE4 in KCNQ1-expressing oocytes suggested that KCNE4 exerts its effect on KCNQ1 channels already expressed in the plasma membrane. This notion was supported by immunocytochemical studies and Western blotting, showing no significant difference in plasma membrane expression of KCNQ1 channels in the presence or absence of KCNE4. The impact of KCNE4 on KCNQ1 was specific since no effect of KCNE4 could be detected if co-expressed with KCNQ2-5 channels or hERG1 channels. RT-PCR studies revealed high KCNE4 expression in embryos and adult uterus, where significant expression of KCNQ1 channels has also been demonstrated.

PubMed ID: 12096056
PMC ID: PMC2290389
Article link: J Physiol

Species referenced: Xenopus
Genes referenced: kcne4 kcnh2 kcnq1 kcnq2

References [+] :
Abbott, MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. 2001, Pubmed, Xenbase