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Biochem Biophys Res Commun 2002 Jul 05;2951:85-91. doi: 10.1016/S0006-291X(02)00641-1.
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Molecular cloning and characterization of dullard: a novel gene required for neural development.

Satow R , Chan TC , Asashima M .

In a screen for genes expressed in neural tissues and pronephroi, we isolated a novel gene, named dullard. Dullard protein contains the C-terminal conserved domain of NLI-IF (Nuclear LIM Interactor-Interacting Factor), a protein whose function is not yet characterized. Dullard mRNA was maternally derived and localized to the animal hemisphere. At neurula stages, the expression was in neural regions and subsequently localized to neural tissues, branchial arches, and pronephroi. Using antisense morpholino oligonucleotide-mediated inhibition, we showed that dullard was required for neural development. The translational knock-down of dullard resulted in failure of neural tube development and the embryos consequently showed a reduction of head development. Expression of neural marker genes in dullard-inhibited embryos was also suppressed. These results suggest that dullard is necessary for neural development.

PubMed ID: 12083771
Article link: Biochem Biophys Res Commun

Species referenced: Xenopus laevis
Genes referenced: ctdnep1 egr2 en2 gmnn irx1 ldb1 ncam1 otx2 sox15 tubb2b zeb2 zic1 zic3
Morpholinos: ctdnep1 MO1

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