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Dev Cell 2002 Jun 01;26:771-83. doi: 10.1016/s1534-5807(02)00172-7.
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Smad10 is required for formation of the frog nervous system.

LeSueur JA , Fortuno ES , McKay RM , Graff JM .

Before the nervous system establishes its complex array of cell types and connections, multipotent cells are instructed to adopt a neural fate and an anterior-posterior pattern is established. In this report, we show that Smad10, a member of the Smad family of intracellular transducers of TGFbeta signaling, is required for formation of the nervous system. In addition, two types of molecules proposed as key to neural induction and patterning, bone morphogenetic protein (BMP) antagonists and fibroblast growth factor (FGF), require Smad10 for these activities. These data suggest that Smad10 may be a central mediator of the development of the frog nervous system.

PubMed ID: 12062089
Article link: Dev Cell
Grant support: [+]

Species referenced: Xenopus
Genes referenced: a2m acta4 actl6a cer1 csnk1e en2 gal.2 gsc hhex hoxc9-like myc myod1 nog nrp1 otx2 smad10 smad4 sox17a sox2 tbx2 tbxt tgfb1
Morpholinos: csnk1e MO1 smad4.2 MO1

Article Images: [+] show captions