Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Dev Cell 2002 Apr 01;24:449-61. doi: 10.1016/s1534-5807(02)00140-5.
Show Gene links Show Anatomy links

Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation.

Cheyette BN , Waxman JS , Miller JR , Takemaru K , Sheldahl LC , Khlebtsova N , Fox EP , Earnest T , Moon RT .

Dapper was isolated in a screen for proteins interacting with Dishevelled, a key factor in Wnt signaling. Dapper and Dishevelled colocalize intracellularly and form a complex with Axin, GSK-3, CKI, and beta-catenin. Overexpression of Dapper increases Axin and GSK-3 in this complex, resulting in decreased soluble beta-catenin and decreased activation of beta-catenin-responsive genes. Dapper also inhibits activation by Dishevelled of c-Jun N-terminal kinase (JNK), a component of beta-catenin-independent Frizzled signaling. Inhibition of Dapper activates both beta-catenin-responsive genes and an AP1-responsive promoter, demonstrating that Dapper is a general Dishevelled antagonist. Depletion of maternal Dapper RNA from Xenopus embryos results in loss of notochord and head structures, demonstrating that Dapper is required for normal vertebrate development.

PubMed ID: 11970895
Article link: Dev Cell
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: csnk1g2 dact1 dvl2 hhat jun mapk8 ppp1r9b uqcc6
Morpholinos: dact1 MO1

Article Images: [+] show captions