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Mech Dev 2002 May 01;1132:131-9. doi: 10.1016/s0925-4773(02)00047-3.
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The small GTPase Rap1 is an immediate downstream target for Hoxb4 transcriptional regulation.

Morsi El-Kadi AS , in der Reiden P , Durston A , Morgan R .

The Hox genes are a family of homeodomain-containing transcription factors which determine anteroposterior identity early on in development. Although a lot is now known about their regulation and function, very little is known of their effector (downstream target) genes. Here we show that the small GTPase Rap1 is a direct, negatively regulated target of Hoxb4 and is excluded from Hoxb4 expressing cells.

PubMed ID: 11960701
Article link: Mech Dev

Species referenced: Xenopus
Genes referenced: dnajc27 hoxb4 mcf2 rap1a

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