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XB-ART-7575
Biosci Biotechnol Biochem 2002 Jan 01;661:185-7.
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Inhibition of translation and progesterone-induced maturation of Xenopus oocytes by expressing the amino-terminal portion of the eukaryotic translation initiation factor 4G.

Wakiyama M , Miura K .


Abstract
The eukaryotic translation initiation factor 4G (eIF4G) plays a pivotal role in translation. EIF4G interacts with several other factors including eIF4E, which is a cap-binding protein, and the poly(A)-binding protein (PABP). In this work, we demonstrate that the expression of the amino-terminal one-third of eIF4G, which interacts with eIF4E and PABP, in Xenopus oocyte inhibits translation and progesterone-induced maturation.

PubMed ID: 11866104
Article link: Biosci Biotechnol Biochem


Species referenced: Xenopus
Genes referenced: eif4e eif4g1 pabpc1 pabpc4