Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-8437
Genomics 2001 Aug 01;761-3:99-109. doi: 10.1006/geno.2001.6606.
Show Gene links Show Anatomy links

Structural conservation of the genes encoding CaT1, CaT2, and related cation channels.

Peng JB , Brown EM , Hediger MA .


Abstract
We report here the genomic structures of the genes encoding human calcium transport proteins CaT1 and CaT2, which belong to a recently identified class of highly selective calcium entry channels. The mRNA for CaT1 was expressed more abundantly than that for CaT2 in three major tissues involved in transcellular calcium transport, namely intestine, kidney, and placenta, as determined by quantitative PCR. The genes encoding CaT1 and CaT2, ECAC2 and ECAC1, respectively, are completely conserved in terms of exon size in the coding regions. They also share similar intron-exon structures with the genes encoding the closely related, nonselective cation channels VR1, VRL-1, OTRPC4 (also known as VR-OAC, Trp12, and VRL-2), and a hypothetical protein, VRL-3. We conclude that ECAC2 and ECAC1, which encode calcium selective channels, share a common ancestral gene with the genes encoding the related nonselective cation channels.

PubMed ID: 11549322
Article link: Genomics
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: cat1 cat2 crata slc7a2 trpv2 trpv4 trpv5