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Development 2001 Sep 01;12817:3381-93. doi: 10.1242/dev.128.17.3381.
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Tumorhead, a Xenopus gene product that inhibits neural differentiation through regulation of proliferation.

Wu CF , Nakamura H , Chan AP , Zhou YH , Cao T , Kuang J , Gong SG , He G , Etkin LD .

Tumorhead (TH) is a novel maternal gene product from Xenopus laevis containing several basic domains and a weak coiled-coil. Overexpression of wild-type TH resulted in increased proliferation of neural plate cells, causing expansion of the neural field followed by neural tube and craniofacial abnormalities. Overexpressed TH protein repressed neural differentiation and neural crest markers, but did not inhibit the neural inducers, pan-neural markers or mesodermal markers. Loss of function by injection of anti-TH antibody inhibited cell proliferation. Our data are consistent with a model in which tumorhead functions in regulating differentiation of the neural tissues but not neural induction or determination through its effect on cell proliferation.

PubMed ID: 11546754
Article link: Development
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: chrd.1 elavl1 myc ncam1 neurod1 not snai1 snai2 sox2 trhd twist1 zic1 zic3
Antibodies: Trhd Ab1
Morpholinos: trhd MO1

Article Images: [+] show captions