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XB-ART-8704
Genes Dev 2001 Jul 15;1514:1759-64. doi: 10.1101/gad.897901.
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Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1.

Pfleger CM , Salic A , Lee E , Kirschner MW .


Abstract
Exit from mitosis requires the degradation of regulatory proteins including the mitotic cyclins and securin through ubiquitination by the anaphase promoting complex (APC) bound to Cdc20 or Cdh1. Cdc20-APC is regulated through inhibition by the spindle assembly checkpoint protein MAD2. Knowledge of Cdh1-APC regulation is limited to the phosphorylation-dependent dissociation of Cdh1 from APC. We report a novel means of regulating Cdh1 by the MAD2-related gene, MAD2L2. MAD2L2 specifically binds and inhibits Cdh1-APC, paralleling the effect of MAD2 on Cdc20. We suggest that MAD2L2 and MAD2 inhibit the release of substrates from APC and propose a mechanism of inhibition.

PubMed ID: 11459825
PMC ID: PMC312740
Article link: Genes Dev
Grant support: [+]

Species referenced: Xenopus
Genes referenced: cdc20 cdh1 mad2l1 mad2l2

References [+] :
Bäumer, Two different modes of cyclin clb2 proteolysis during mitosis in Saccharomyces cerevisiae. 2000, Pubmed