Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-921
FEBS Lett 2006 Jan 09;5801:239-44. doi: 10.1016/j.febslet.2005.12.004.
Show Gene links Show Anatomy links

Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium.

Locovei S , Wang J , Dahl G .


???displayArticle.abstract???
The ability for long-range communication through intercellular calcium waves is inherent to cells of many tissues. A dual propagation mode for these waves includes passage of IP3 through gap junctions as well as an extracellular pathway involving ATP. The wave can be regenerative and include ATP-induced ATP release via an unknown mechanism. Here, we show that pannexin 1 channels can be activated by extracellular ATP acting through purinergic receptors of the P2Y group as well as by cytoplasmic calcium. Based on its properties, including ATP permeability, pannexin 1 may be involved in both initiation and propagation of calcium waves.

???displayArticle.pubmedLink??? 16364313
???displayArticle.link??? FEBS Lett
???displayArticle.grants??? [+]

Species referenced: Xenopus
Genes referenced: panx1