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XB-ART-9649
Neuron 2000 Dec 01;283:665-79. doi: 10.1016/s0896-6273(00)00145-8.
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LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome.

Feng Y , Olson EC , Stukenberg PT , Flanagan LA , Kirschner MW , Walsh CA .


Abstract
LIS1, a microtubule-associated protein, is required for neuronal migration, but the precise mechanism of LIS1 function is unknown. We identified a LIS1 interacting protein encoded by a mouse homolog of NUDE, a nuclear distribution gene in A. nidulans and a multicopy suppressor of the LIS1 homolog, NUDF. mNudE is located in the centrosome or microtubule organizing center (MTOC), and interacts with six different centrosomal proteins. Overexpression of mNudE dissociates gamma-tubulin from the centrosome and disrupts microtubule organization. Missense mutations that disrupt LIS1 function block LIS1-mNudE binding. Moreover, misexpression of the LIS1 binding domain of mNudE in Xenopus embryos disrupts the architecture and lamination of the CNS. Thus, LIS1-mNudE interactions may regulate neuronal migration through dynamic reorganization of the MTOC.

PubMed ID: 11163258
Article link: Neuron
Grant support: [+]

Species referenced: Xenopus
Genes referenced: ccp110 dcx nde1 ndel1 pafah1b1 pcnt tcp1


Article Images: [+] show captions
References :
Reiner, LIS1. let's interact sometimes... (part 1). 2001, Pubmed