Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-9929
Mech Dev 2000 Dec 01;991-2:3-14. doi: 10.1016/s0925-4773(00)00465-2.
Show Gene links Show Anatomy links

Expression cloning of Xantivin, a Xenopus lefty/antivin-related gene, involved in the regulation of activin signaling during mesoderm induction.

Tanegashima K , Yokota C , Takahashi S , Asashima M .


???displayArticle.abstract???
In a screening for activin-responsive genes, we isolated a Xenopus lefty/antivin-related gene, called Xantivin (Xatv). In the animal cap assay, the expression of Xatv was induced by activin signaling, and in the embryo, by nodal-related genes. Overexpression of Xatv in the marginal zone caused suppression of mesoderm formation and gastrulation defects, and inhibited the secondary axis formation induced by Xnr1 and Xactivin, suggesting that Xatv acted as a feedback inhibitor of activin signaling. However, in the animal cap, Xatv failed to antagonize Xnr1 and Xactivin. This result suggested that Xatv has different responses in the marginal zone and in the animal region, and antagonizes to a higher degree activin signaling in the marginal zone.

???displayArticle.pubmedLink??? 11091069
???displayArticle.link??? Mech Dev


Species referenced: Xenopus
Genes referenced: lefty nodal nodal1


???attribute.lit??? ???displayArticles.show???