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XB-ANTIBODY-23622609

Antibody Name: Casp3.2 Ab10

Common Name: cleaved caspase-3

RRID: AB_2341188
Synonyms: 9661, Caspase-3, apoptain, cpp-21

Antigens

Clone Type: Polyclonal
Source: Cell Signaling Technology

Antibody
Clone Number
Purification
Isotype isotype unknown
Host Organism rabbit
Xenopus Reactivity X. laevis
Non-Xenopus Reactivity human, monkey, mouse, rat
Description: Cleaved Caspase-3 (Asp175) Antibody detects endogenous levels of the large fragment (17/19 kDa) of activated caspase-3 resulting from cleavage adjacent to Asp175. This antibody does not recognize full length caspase-3 or other cleaved caspases. Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 fragments. Cleavage of caspase-3 requires the aspartic acid residue at the P1 position (2). Citation:(Cell Signaling Technology Cat# 9661, RRID:AB_2341188)
Immunogen
Name casp3.2
Type polypeptide
Post Translational Modifications None
Source Organism frog
Description Cleaved Caspase-3 (Asp175) Antibody detects endogenous levels of the large fragment (17/19 kDa) of activated caspase-3 resulting from cleavage adjacent to Asp175. This antibody does not recognize full length caspase-3 or other cleaved caspases.
Sequence
Reported Usage
Publications
First: Bisphenol A exposure induces apoptosis and impairs early embryonic development in Xenopus laevis., Environ Pollut 2021  
Most recent: Developmental regulation of cellular metabolism is required for intestinal elongation and rotation., Development 2024                                        
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