Larger Image Figure 9. Gating attributes of mutant IKs channels. (A) Normalized open probabilities (I/IMax) for cells with D76N IKs channels (•, z = 1.3 ± 0.2), S74L IKs channels (▾, z = 1.6 ± 0.1), and S74L-D76N IKs channels (♦, z = 1.3 ± 0.2); protocols, theoretical fits, and equivalent valences (z) as in Fig. 5; the dotted line is the curve for wild-type IKs channels from Fig. 5 A. (B) Normalized tail currents at −60 mV for D76N, S74L, and D76N-S74L IKs channels; the dotted line is the curve for wild-type IKs channels from Fig. 5 B. Currents were elicited after a 6-s test pulse to 80 mV. Theoretical lines were constructed as described in the legend to Table I. Image published in: Sesti F and Goldstein SA (1998) Image reproduced on Xenbase with permission of the publisher and the copyright holder. Creative Commons Attribution-NonCommercial-ShareAlike license Permanent Image Page Printer Friendly View XB-IMG-120952