Figure S3B. Inhibition of dopamine transport by AmDAT by the presence of cocaine. The figure presents an example of the inability of cocaine to produce a current in AmDAT expressing oocytes, supported by a significantly smaller normalised current (Mean 3.4 S.E.M. 1.7 p<0.001). Currents induced with a dopamine/cocaine mix were significantly smaller than currents induced by dopamine alone (Mean 61.6 S.E.M. 4.9 p < 0.001) (Figure 3), indicating the inhibition of AmDAT-mediated dopamine transport by cocaine. Currents could still be induced with dopamine after superfusion with cocaine or a dopamine/cocaine mix, showing that cocaine binds to AmDAT in a reversible manner.
Image published in: Zhang V et al. (2019)
Copyright © 2019 Zhang, Kucharski, Landers, Richards, Bröer, Martin and Maleszka. Creative Commons Attribution license
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