Images

Sources

Experiment + Assay

Phenotypes

Human Diseases

Fig. 4a,b, e, f, k, l, m, n

Sempou E et al. (2022)

Xtr Wt + kcnh6 CRISPR (400pg)

NF10 (in situ hybridization)

Anatomical Phenotype
abnormal gastrulation abnormal mesoderm

Expression Phenotype
increased amount pou5f3.1 expression in embryo absent myod1 expression in dorso-lateral marginal zone decreased amount pou5f3.3 expression in embryo decreased amount sox2 expression in dorsal side decreased amount trim33 expression in animal cap decreased amount trim33 expression in endomesoderm increased amount ventx1.2 expression in embryo

Suppl. Fig. 6 b r1_c3, r2_c3

Sempou E et al. (2022)

Xtr Wt + kcnh6 CRISPR (400pg)

NF12 (in situ hybridization)

Expression Phenotype
increased amount pou5f3.1 expression in embryo increased amount ventx1.2 expression in animal pole increased amount ventx1.2 expression in ventral marginal zone

Fig. 4 row 2 col 4

Jalvy S et al. (2019)

Xla Wt + lif

NF 12.5 (RT-PCR)

Expression Phenotype
increased amount pou5f3.1.L expression in embryo