Fig. 1EF

Jourdeuil K et al. (2025)

Xla Wt + zmym2

NF22-23 (in situ hybridization)

Expression Phenotype
decreased amount six1.L expression in preplacodal ectoderm decreased amount irx1.L expression in preplacodal ectoderm decreased amount sox11.L expression in preplacodal ectoderm

Fig. 3 (gastrula)

Damuth DL et al. (2024)

Xla Wt + Xla.sox21.L

NF11-11.5 (RT-PCR)

Expression Phenotype
increased amount six1.L expression in preplacodal ectoderm increased amount myt1.L expression in neural stem cell

Fig. 3 (neurula)

Damuth DL et al. (2024)

Xla Wt + Xla.sox21.S

NF15 (RT-PCR)

Expression Phenotype
increased amount six1.L expression in preplacodal ectoderm decreased amount sox2.L expression in neural stem cell decreased amount tubb2b.L expression in neuron increased amount myt1.L expression in neural stem cell increased amount neurod1.L expression in neural progenitor cell

Fig. 5 FG

Devotta A et al. (2023)

Xla wt + A71915 (npr1 antagonist)

NF15 (in situ hybridization)

Expression Phenotype
decreased amount six1.L expression in anterior placodal area decreased amount snai2.L expression in neural crest

Fig 2 FG

Devotta A et al. (2023)

Xla wt + AP-811 (npr3 antagonist)

NF15 (in situ hybridization)

Expression Phenotype
absent six1.L expression in anterior placodal area

Fig 6 Ar1 B

Devotta A et al. (2023)

Xla Wt + nppa MO

NF15 (in situ hybridization)

Expression Phenotype
decreased amount six1.L expression in anterior placodal area absent sox10.L expression in cranial neural crest decreased amount snai2.L expression in neural crest increased amount sox2.L expression in neural plate

Fig 6 A:r3 BDE

Devotta A et al. (2023)

Xla Wt + nppc MO

NF15 (in situ hybridization)

Expression Phenotype
absent six1.L expression in anterior placodal area absent sox10.L expression in cranial neural crest decreased amount snai2.L expression in neural crest increased amount sox2.L expression in neural plate

Fig. 5 B:c2r1 CD

Devotta A et al. (2023)

Xla Wt + npr1 MO

NF15 (in situ hybridization)

Expression Phenotype
absent six1.L expression in anterior placodal area absent snai2.L expression in neural crest absent sox10.L expression in cranial neural crest

Fig. 2 CD

Devotta A et al. (2023)

Xla Wt + npr3 MO

NF15 (in situ hybridization)

Expression Phenotype
decreased amount six1.L expression in anterior placodal area decreased amount foxi4.1.L expression in anterior placodal area decreased amount snai2.L expression in neural crest decreased amount sox10.L expression in neural crest increased amount sox2.L expression in neural plate

Fig. 4 AB

Devotta A et al. (2023)

Xla Wt + npr3 MO

NF15 (in situ hybridization)

Expression Phenotype
decreased amount six1.L expression in anterior placodal area