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XB-PHENO-25791

Xla Wt + Hsa.RAF1, Wong S et al. (2023)

Experiment + Assay: Xla Wt + Hsa.RAF1 + NF28 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
mRNA injection   raf1 (Xla)
 NF stage 3 (4-cell) blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 28  
Anatomical Phenotypes: abnormal spinal cord morphology , duplicated tail
Expression Phenotypes (4):
increased amount tbxt.L expression in anterior neural tube
mislocalised tbxt.L expression in chordoneural hinge
mislocalised tbxt.L expression in tail tip
mislocalised tubb2b.L expression in ventral side
Source: Fig. 2E r1c2, r2c2
Article: XB-ART-59687, PubMed