Search Lines and Strains
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| Line Name | Species | Mutated Gene(s) | Description | Availability |
| Xla.hmgcremHorb | X. laevis | hmgcr.L | CRISPR knockout of hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase). Germline transmission confirmed... | |
| Xtr.bhlhe22emHorb | X. tropicalis | bhlhe22 | CRISPR knockout of bhlhee2 (basic helix-loop-helix family member e22), Current mosaic founders, Conf... | |
| Xtr.kng1emHorb | X. tropicalis | kng1 | CRISPR knockout of kng1 (kininogen 1), Germline transmission confirmed. Mutants carry a bp deletion ... | |
| Xtr.fibinemHorb | X. tropicalis | fibin | CRISPR knockout of fibin (fin bud initiation factor homolog), Confirmed germline transmission. Custo... | |
| Xtr.tbx5emHorb | X. tropicalis | tbx5 | CRISPR knockout of tbx5 (T-box 5 ), Confirmed germline transmission. Custom mutant generated by Horb... | |
| Xtr.tyremNXR | X. tropicalis | tyr | CRISPR knockout of tyr (tyrosinase), Confirmed germline transmission. Animal carry a 241bp insertion... | |
| Xtr.raxmGrngr | X. tropicalis | rax | This mutant line was generated in an ENU screen from the Grainger lab by TILLING (Targeting Induced ... | |
| Xla.Tg(Xtr.hal2:eGFP;cryga:GFP3)Shi | X. laevis | This tg line carries a 4.4-kb HAL2 promoter in AcGFP1.1 vexctor , subcloned into the KpnI-AgeI diges... | ||
| Xtr.Tg(otx2:Gal4;cryga:eCFP)Zimml | X. tropicalis | Otx2 promoter driving Gal4 expression in eye region. Transgene is marked by eCFP expression in lens ... | ||
| Xtr.Tg(otx2:Gal4)Zimml | X. tropicalis | Otx2 promoter driving Gal4 expression. | ||
| Xtr.Tg(rax:Gal4;cryga:eCFP)Zimml | X. tropicalis | 2.2Kb retina and anterior neural fold homeobox (rax) promoter driving expression of Gal4. Transgene ... | ||
| Xtr.Tg(UAS:dkk1;cryga:RFP)Zimml | X. tropicalis | Gal4 responsive UAS promoter driving FLAG tagged dickkopf WNT signaling pathway inhibitor 1 (dkk1) e... | ||
| Xtr.Tg(UAS:Hsa.NOG-mGFP;actc1:RFP)Zimml | X. tropicalis | Gal4 responsive UAS element driving expression of a human noggin-GFP fusion protein. | ||
| Xtr.Tg(UAS:cer1;cryga:RFP)Zimml | X. tropicalis | Gal4 responsive UAS element driving expression of cerberus (cer1). Transgene marked by gamma-crystal... | ||
| Xtr.Tg(UAS:Hsa.HHIP;cryga:RFP)Zimml | X. tropicalis | Gal4 responsive UAS promoter drives human hedgehog interacting protein (HHIP). Linked to gamma cryst... | ||
| Xtr.Tg(pax6:PR-Gal4-VP16;cryga:eCFP)Zimml | X. tropicalis | Pax6 promoter driving RU486-inducible progesterone receptor (PR)/Gal4/VP16 transactivator. Linked to... | ||
| Xtr.Tg(myl2:Gal4;cryga:CFP)Zimml | X. tropicalis | Myosin light chain 2 (myl2) promoter driving Gal4 expression in heart.Linked to crystallin promoter ... | ||
| Xtr.Tg(myl2:GFP)Zimml | X. tropicalis | Cardiac myosin light chain 2 (myl2) promoter driving GFP expression. | ||
| Xtr.Tg(Dre.mnx1:GFP)Dorey | X. tropicalis | Zebrafish motor neuron and pancreas homeobox 1 gene (Dre.mnx1) promoter driving GFP expression. | ||
| Xtr.Tg(nectin2:Venus;cryga:RFP)Amaya | X. tropicalis | Xenopus nectin2 promoter drives Venus expression, and crystallin gamma A (cryga) driving RFP used as... | ||
| Xtr.Tg(vim:Venus;cryga:GFP)Amaya | X. tropicalis | Vimentin promoter driving Venus (a yellow FP), and gamma-crystalin (cryga) driving GFP as the marker... | ||
| Xtr.Tg(Hsa.UBC:Gal4-VP16;cryga:CFP)Amaya | X. tropicalis | Human Ubiquitin C (Hsa.UBC) promoter driving Gal4-VP16 fusion construct, with gamma-crystallin (cryg... | ||
| Xtr.Tg(hsp70:dnfgfr-Venus:cryga:RFP)Amaya | X. tropicalis | HSP70 heat shock inducible promoter driving dominant negative fgf receptor ((fgfr) with intracellula... | ||
| Xtr.Tg(UAS:mapt-Venus:Hsa.UBC:Gal4-VP16)Amaya | X. tropicalis | UAS driving mapt-Venus fusion expresssion to label mictrotubules. Ubiquitous Gal4-VP16 fusion expres... | ||
| Xtr.Tg(UAS:msn-mCherry;cryga:RFP)Amaya | X. tropicalis | UAS driving mCherry-Moesin with crystallin-RFP. | ||
| Xtr.Tg(Hsa.UBC:hist2h2be-mCherry)Amaya | X. tropicalis | Human Ubiquitin C (UBC) promoter driving expression of an H2B-mCherry fusion protein, ubiquitous nuc... | ||
| Xtr.Tg(Hsa.UBC:lyn-Venus)Amaya | X. tropicalis | Human Ubiquitin C (Hsa.UBC) promoter driving expression of a LYN proto-oncogene, Src family tyrosine... | ||
| Xtr.Tg(CMV:dTomato)Amaya | X. tropicalis | CMV promoter driving dTomato. | ||
| Xtr.Tg(cdknx:GFP)Papal | X. tropicalis | cyclin-dependent kinase inhibitor (cdknx, previously called Xic1) promoter driving GFP. | ||
| Xtr.Tg(Mmu.Tek:GFP)Amaya | X. tropicalis | Mouse Tie2 (Tek) promoter driving GFP expression. | ||
| Xtr.Tg(Xla.actc1:GFP)Mohun | X. tropicalis | 580 bp promoter of X. laevis cardiac actin gene driving expression of GFP. | ||
| Xtr.Tg(pax6:GFP)Amaya | X. tropicalis | 3.6kb Xenopus paired box 6 ( pax6) promoter driving GFP. | ||
| Xtr.Tg(tubb2b:Hsa.ALPP;cryga:dsRed)Amaya | X. tropicalis | Neural expression of human placental alkaline phosphatase (Hsa.ALPP) driven by N-beta-tubulin (tubb2... | ||
| Xtr.Tg(tubb2b:mapt-GFP)Amaya | X. tropicalis | 3481 bp N-beta-tubulin(tubb2b) promoter and 5'UTR driving expression of mapt-GFP fusion (tauGFP) in ... | ||
| Xtr.Tg(tubb2b:GFP)Amaya | X. tropicalis | Xenopus n-tubulin (tubb2b) promoter driving GFP. | ||
| Xla.wnt11emHorb | X. laevis | wnt11.L wnt11.S | Double CRISPR knockout of wnt11 (Wnt family member 11) in X. laevis, Confirmed germline transmission... | NXR |
| Xla.wdpcpemHorb | X. laevis | wdpcp.L | CRISPR knockout of wdpcp (WD repeat containing planar cell polarity effector). Germ line transmissio... | NXR |
| Xla.olig2emHorb | X. laevis | olig2.L | CRISPR knockout of olig2 (oligodendrocyte lineage transcription factor 2) in X. laevis. KOs both oli... | |
| Xla.notch4emHorb | X. laevis | notch4.S | TALEN knockout of notch4 in X. laevis. THIS LINE is no longer available from the NXR | |
| Xla.mcidasemHorb | X. laevis | mcidas.L | CRISPR knockout of mcidas (multiciliate differentiation and DNA synthesis associated cell cycle prot... | |
| Xla.sox10emHorb | X. laevis | sox10.L sox10.S | Probable double CRISPR knockout of sox10 (SRY-box 10). Confirmed germline transmission in sox10.L (W... | NXR |
| Xla.slc16a2emHorb | X. laevis | slc16a2.L slc16a2.S | Double CRISPR knockout of slc16a2 (solute carrier family 16, member 2 (thyroid hormone transporter))... | NXR |
| Xla.mitfemHorb | X. laevis | mitf.L | CRISPR knockout of mitf (melanocyte inducing transcription factor) Germ line transmission confirmed.... | |
| Xla.prph2emHorb | X. laevis | prph2.L prph2.S | X. laevis CRISPR knockout line of prph2 (peripherin 2 (retinal degeneration, slow)). Mutant line gen... | |
| Xla.gfi1emHorb | X. laevis | gfi1.L | CRISPR knockout of gfi1 (growth factor independent 1 transcription repressor ).Confirmed germline tr... | |
| Xla.prickle1emHorb | X. laevis | prickle1.L prickle1.S | CRISPR knockout of prickle1(prickle planar cell polarity protein 1). Confirmed germ line transmissio... | NXR |
| Xla.fxr1emHorb | X. laevis | fxr1.L | CRISPR Knockout of fxr1(FMR1 autosomal homolog 1 ). Currently mosaic founders. Confirmed germline tr... | |
| Xla.eya1emHorb | X. laevis | eya1.L | CRISPR Knockout of eya1 (EYA transcriptional coactivator and phosphatase 1) .gRNAs target eya1.L and... | |
| Xla.ppp2r2aemHorb | X. laevis | ppp2r2a.L | CRISPR knockout of ppp2r2a (protein phosphatase 2 regulatory subunit B, alpha ). Current mosaic foun... | NXR |
| Xla.aqp1emHorb | X. laevis | aqp1.L | CRISPR Knockout of aqp1.L and aqp1.S (Aquaporin1) Germline transmission confirmed. Mutation is a 1... |
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