Search Lines and Strains
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| Line Name | Species | Mutated Gene(s) | Description | Availability |
| Xtr.mapk10emHorb | X. tropicalis | mapk10 | CRISPR knockout of mapk10 (mitogen-activated protein kinase 10), Germ line transmission confirmed. A... | NXR |
| Xtr.icam5emHorb | X. tropicalis | icam5 | CRISPR knockout of icam5 (intercellular adhesion molecule 5), Germ line transmission confirmed. Anim... | NXR |
| Xtr.sox3emHorb | X. tropicalis | sox3 | CRISPR knockout of sox3 (SRY-box 3). Germline transmission not yet confirmed. Custom mutant generate... | NXR |
| Xla.Tg(tuba1a:deup1-eGFP)NXR | X. laevis | Tubulin promoter driving expression of deup1 fused to eGFP labeling both deuterosomes and centrioles... | NXR | |
| Xtr.ezh2emHorb | X. tropicalis | ezh2 | CRISPR knockout of ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit), Germ line trans... | NXR |
| Xtr.tbx2emHorb | X. tropicalis | tbx2 | CRISPR knockout of tbx2 (T-box 2). Germline transmission confirmed. Animals carry a 4 base pair dele... | NXR |
| Xtr.zbtb14emHorb | X. tropicalis | zbtb14 | CRISPR knockout of zbtb14 (zinc finger and BTB domain containing 14). Germ line transmission confirm... | NXR |
| Xtr.notch4emHorb | X. tropicalis | notch4 | CRISPR knockout of notch4 in X. tropicalis. Confirmed germline transmission. Mutation characterized:... | NXR |
| Xtr.tlx3em2Horb | X. tropicalis | tlx3 | CRISPR mutant line targeting tlx3 (T cell leukemia homeobox 3). Germ lIne transmission confirmed. An... | NXR |
| Xtr.runx1t1emHorb | X. tropicalis | runx1t1 | CRISPR knockout of runx1t1(RUNX1 partner transcriptional co-repressor 1) gene. Germ line transmissio... | NXR |
| Xla.hmgcremHorb | X. laevis | hmgcr.L hmgcr.S | CRISPR knockout of hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase). Germline transmission confirmed... | NXR |
| Xtr.bhlhe22emHorb | X. tropicalis | bhlhe22 | CRISPR knockout of bhlhe22 (basic helix-loop-helix family member e22), Germ line transmission confir... | NXR |
| Xtr.kng1emHorb | X. tropicalis | kng1 | CRISPR knockout of kng1 (kininogen 1), Germline transmission confirmed. Mutants carry a 4 base pair ... | NXR |
| Xtr.fibinemHorb | X. tropicalis | fibin | CRISPR knockout of fibin (fin bud initiation factor homolog), Confirmed germline transmission. Custo... | NXR |
| Xtr.tbx5emHorb | X. tropicalis | tbx5 | CRISPR knockout of tbx5 (T-box 5 ). Germline transmission not yet confirmed. Contact the NXR for mor... | NXR |
| Xtr.tyremNXR | X. tropicalis | tyr | CRISPR knockout of tyr (tyrosinase), Confirmed germline transmission. Animal carry a 241bp insertion... | |
| Xtr.raxmGrngr | X. tropicalis | rax | This mutant line was generated in an ENU screen from the Grainger lab by TILLING (Targeting Induced ... | |
| Xla.Tg(Xtr.hal2:eGFP;cryga:GFP3)Shi | X. laevis | This tg line carries a 4.4-kb HAL2 promoter in AcGFP1.1 vexctor , subcloned into the KpnI-AgeI diges... | ||
| Xtr.Tg(otx2:Gal4;cryga:eCFP)Zimml | X. tropicalis | Otx2 promoter driving Gal4 expression in eye region. Transgene is marked by eCFP expression in lens ... | ||
| Xtr.Tg(otx2:Gal4)Zimml | X. tropicalis | Otx2 promoter driving Gal4 expression. | ||
| Xtr.Tg(rax:Gal4;cryga:eCFP)Zimml | X. tropicalis | 2.2Kb retina and anterior neural fold homeobox (rax) promoter driving expression of Gal4. Transgene ... | ||
| Xtr.Tg(UAS:dkk1;cryga:RFP)Zimml | X. tropicalis | Gal4 responsive UAS promoter driving FLAG tagged dickkopf WNT signaling pathway inhibitor 1 (dkk1) e... | ||
| Xtr.Tg(UAS:Hsa.NOG-mGFP;actc1:RFP)Zimml | X. tropicalis | Gal4 responsive UAS element driving expression of a human noggin-GFP fusion protein. | ||
| Xtr.Tg(UAS:cer1;cryga:RFP)Zimml | X. tropicalis | Gal4 responsive UAS element driving expression of cerberus (cer1). Transgene marked by gamma-crystal... | ||
| Xtr.Tg(UAS:Hsa.HHIP;cryga:RFP)Zimml | X. tropicalis | Gal4 responsive UAS promoter drives human hedgehog interacting protein (HHIP). Linked to gamma cryst... | ||
| Xtr.Tg(pax6:PR-Gal4-VP16;cryga:eCFP)Zimml | X. tropicalis | Pax6 promoter driving RU486-inducible progesterone receptor (PR)/Gal4/VP16 transactivator. Linked to... | NXR | |
| Xtr.Tg(myl2:Gal4;cryga:CFP)Zimml | X. tropicalis | Myosin light chain 2 (myl2) promoter driving Gal4 expression in heart.Linked to crystallin promoter ... | ||
| Xtr.Tg(myl2:GFP)Zimml | X. tropicalis | Cardiac myosin light chain 2 (myl2) promoter driving GFP expression. | ||
| Xtr.Tg(Dre.mnx1:GFP)Dorey | X. tropicalis | Zebrafish motor neuron and pancreas homeobox 1 gene (Dre.mnx1) promoter driving GFP expression. | NXR | |
| Xtr.Tg(nectin2:Venus;cryga:RFP)Amaya | X. tropicalis | Xenopus nectin2 promoter drives Venus expression, and crystallin gamma A (cryga) driving RFP used as... | ||
| Xtr.Tg(vim:Venus;cryga:GFP)Amaya | X. tropicalis | Vimentin promoter driving Venus (a yellow FP), and gamma-crystalin (cryga) driving GFP as the marker... | NXR | |
| Xtr.Tg(Hsa.UBC:Gal4-VP16;cryga:CFP)Amaya | X. tropicalis | Human Ubiquitin C (Hsa.UBC) promoter driving Gal4-VP16 fusion construct, with gamma-crystallin (cryg... | ||
| Xtr.Tg(hsp70:dnfgfr-Venus:cryga:RFP)Amaya | X. tropicalis | HSP70 heat shock inducible promoter driving dominant negative fgf receptor ((fgfr) with intracellula... | ||
| Xtr.Tg(UAS:mapt-Venus:Hsa.UBC:Gal4-VP16)Amaya | X. tropicalis | UAS driving mapt-Venus fusion expresssion to label mictrotubules. Ubiquitous Gal4-VP16 fusion expres... | ||
| Xtr.Tg(UAS:msn-mCherry;cryga:RFP)Amaya | X. tropicalis | UAS driving mCherry-Moesin with crystallin-RFP. | NXR | |
| Xtr.Tg(Hsa.UBC:hist2h2be-mCherry)Amaya | X. tropicalis | Human Ubiquitin C (UBC) promoter driving expression of an H2B-mCherry fusion protein, ubiquitous nuc... | ||
| Xtr.Tg(Hsa.UBC:lyn-Venus)Amaya | X. tropicalis | Human Ubiquitin C (Hsa.UBC) promoter driving expression of a LYN proto-oncogene, Src family tyrosine... | NXR | |
| Xtr.Tg(CMV:dTomato)Amaya | X. tropicalis | CMV promoter driving dTomato. | ||
| Xtr.Tg(cdknx:GFP)Papal | X. tropicalis | cyclin-dependent kinase inhibitor (cdknx, previously called Xic1) promoter driving GFP. | ||
| Xtr.Tg(Mmu.Tek:GFP)Amaya | X. tropicalis | Mouse Tie2 (Tek) promoter driving GFP expression. | ||
| Xtr.Tg(Xla.actc1:GFP)Mohun | X. tropicalis | 580 bp promoter of X. laevis cardiac actin gene driving expression of GFP. | ||
| Xtr.Tg(pax6:GFP)Amaya | X. tropicalis | 3.6kb Xenopus paired box 6 ( pax6) promoter driving GFP. | NXR | |
| Xtr.Tg(tubb2b:Hsa.ALPP;cryga:dsRed)Amaya | X. tropicalis | Neural expression of human placental alkaline phosphatase (Hsa.ALPP) driven by N-beta-tubulin (tubb2... | ||
| Xtr.Tg(tubb2b:mapt-GFP)Amaya | X. tropicalis | 3481 bp N-beta-tubulin(tubb2b) promoter and 5'UTR driving expression of mapt-GFP fusion (tauGFP) in ... | EXRC | |
| Xtr.Tg(tubb2b:GFP)Amaya | X. tropicalis | Xenopus n-tubulin (tubb2b) promoter driving GFP. | NXR | |
| Xla.wnt11emHorb | X. laevis | wnt11.L wnt11.S | Double CRISPR knockout of wnt11 (Wnt family member 11) in X. laevis, Confirmed germline transmission... | NXR |
| Xla.wdpcpemHorb | X. laevis | wdpcp.L | CRISPR knockout of wdpcp (WD repeat containing planar cell polarity effector). Germ line transmissio... | NXR |
| Xla.olig2emHorb | X. laevis | olig2.L | CRISPR mutant is not available in the NXR. Contact for more details. | |
| Xla.notch4emHorb | X. laevis | notch4.S | TALEN knockout of notch4 in X. laevis. No longer available at NXR- generated a new CRSIPR line in X.... | |
| Xla.mcidasemHorb | X. laevis | mcidas.L | CRISPR knockout of mcidas (multiciliate differentiation and DNA synthesis associated cell cycle prot... |
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