Search Lines and Strains
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| Line Name | Species | Mutated Gene(s) | Description | Availability |
| Xtr.rspo2 em2NXR | X. tropicalis | rspo2 | CRISPR knockout of rspo2 (R-spondin 2). Germ line transmission confirmed. Animals carry a 10 base pa... | NXR |
| Xtr.nagluem1NXR | X. tropicalis | naglu | CRISPR knockout of naglu (N-acetyl-alpha-glucosaminidase) gene. Germ line transmission confirmed. An... | NXR |
| Xtr.olig2emHorb | X. tropicalis | olig2 | CRISPR knockout of olig2 (oligodendrocyte lineage transcription factor 2) in X. tropicalis. Confirme... | NXR |
| Xtr.NigerianKhok | X. tropicalis | These are inbred Nigerian X. tropicalis kindly provided to the Harland lab by Rob Grainger, then bre... | ||
| Xla.Tg(sox10:GFP)Jpsj | X. laevis | sox10:GFP-HS4-Isce1 transgene contains 4.7Kb of upstream sequence from the transcription factor sox1... | NXR | |
| Xtr.Et(eef1a1:GFP)psvbiMead | X. tropicalis | Tol2 transposon harboring a Xenopus ef1a promoter driving expression of GFP. | NXR | |
| Xtr.tlx3em1Horb | X. tropicalis | tlx3 | CRISPR knockout of tlx3 (T cell leukemia homeobox 3). Confirmed germline transmission. Custom mutant... | NXR |
| Xla.Tg(CMV:Brainbow1.0L)NXR | X. laevis | To generate original lines of mice expressing Brainbow in neurons, the Brainbow-1 and Brainbow-2 con... | NXR | |
| Xla.tracemHorb | X. laevis | trac.L | CRISPR line targeting trac (T cell receptor alpha constant), a gene associated with immunodeficiency... | NXR |
| Xla.Tg(CMV:eCFP,eYFP)1Ryff | X. laevis | CMV promoter driving the expression of eCFP or eYFP. The eCFP coding sequence and its polyadenylatio... | ||
| Xla.Tg(Mmu.tal1:GFP)1Patnt | X. laevis | Mouse SCL +19 enhancer which contains a GATA-ETS-GATA core motif driving GFP (SCL= tal1). Lab of ori... | ||
| Xtr.rflciiemNXR | X. tropicalis | rflcii | CRISPR knockout of rflcii (relaxin family locus C type II ) in X tropicalis. Germ line transmission ... | NXR |
| Xla.outbredKXRCR | X. laevis | |||
| Xtr.Ivory Coast TGA (homozygous blue) | X. tropicalis | Originally derived from animals obtained by the Harland group from Nicolas Pollet inbreeding produce... | ||
| Xtr.sox2emHorb | X. tropicalis | sox2 | CRISPR knockout of sox2 (SRY-box 2). Custom mutant line. Germ line transmission confirmed. Animals c... | NXR |
| Xla.Tg(cryga:eGFP)Amaya | X. laevis | The crystallin-GFP construct was generated by subcloning a 2.2 kb fragment of the crystalline genomi... | ||
| Xtr.snai1emNXR | X. tropicalis | snai1 | CRISPR knockout of snai1 (snail family zinc finger 1) in X. tropicalis. germline transmission confir... | NXR |
| Xtr.frzb,frzb2emHorb | X. tropicalis | frzb frzb2 | double CRISPR knockout of frzb (frizzled related protein ) and frzb2 (frizzled related protein 2). C... | |
| Xla.Tg(myl7:Gal4;UAS:adprhl1m)Mohun | X. laevis | The Xenopus form of the adprhl1 gene with silent mutations to escape regulatory repression in the h... | ||
| Xtr.celf3emNXR | X. tropicalis | celf3 | CRISPR knock out of celf3 (CUGBP, Elav-like family member 3). Germ line transmission not yet confirm... | NXR |
| Xla.tyremNXR | X. laevis | tyr.L | TALEN induced tyrosinase mutant. Custom line made by the NXR. Contact NXR for details. | |
| Xtr.foxl2em2NXR | X. tropicalis | foxl2 | CRISPR knockout of foxl2 (forkhead box L2). Germline transmission confirmed. Animals carry a 1 base ... | NXR |
| Xla.Tg(Hsa.CSN1:beta-globin-eGFP)Umbhauer | X. laevis | CNS1 sequences were inserted upstream of a human β-globin basal promoter (− 37 to + 12) followed by ... | ||
| Xtr.Tg(WntREs:dEGFP;CMV:dsRed)Vlemx | X. tropicalis | The inserted transgene construct contains a synthetic Wnt-responsive promoter consisting of 7 copies... | ||
| Xtr.legmZimml | X. tropicalis | unknown | Mutation affecting otoconia formation identified in the Mill Hill screen of ENU-induced mutations. | |
| Xtr.hey2emHorb | X. tropicalis | hey2 | CRISPR knockout of hey2 (hes related family bHLH transcription factor with YRPW motif 2). Germline t... | NXR |
| Xtr.naa20emNXR | X. tropicalis | naa20 | CRISPR knockout fo naa20 (N(alpha)-acetyltransferase 20, NatB catalytic subunit ). Germ line transmi... | NXR |
| Xtr.foxp3em2NXR | X. tropicalis | foxp3 | CRISPR knockout of foxp3 (forkhead box P3). Germ line transmission confirmed. Animals carry a 17 bas... | NXR |
| Xtr.mapk10emHorb | X. tropicalis | mapk10 | CRISPR knockout of mapk10 (mitogen-activated protein kinase 10), Germ line transmission confirmed. A... | NXR |
| Xtr.Tg(mlc2:dnfosl1-eGFP)Qi | X. tropicalis | fosl1 | Fosl1 protein was mutated and truncated to generate 3 mutant polypeptides which then cloned into pc... | |
| Xla.Tg(rho:eGFP-atp1a3)Baker | X. laevis | Xenopus rhodopsin (rho) promoter driving expression of eGFP tagged neuronal alpha-3 isoform of the N... | ||
| Xla.tap2emNXR | X. laevis | tap2.L | X. laevis CRISPR line targeting tap2 (transporter 2, ATP-binding cassette, sub-family B (MDR/TAP). G... | NXR |
| Xtr.lamp2emHorb | X. tropicalis | lamp2 | CRISPR knockout of lamp2 (lysosomal associated membrane protein 2 ). Germ line transmission confirme... | NXR |
| Xla.Tg(Xtr.col2a1:eGFP;cryga:GFP)Hank | X. laevis | X. laevis line with X. tropicalis (Xtr) collagen 2a1 (col2a1) promoter and first intron, driving eG... | ||
| Xtr.raxmGrngr | X. tropicalis | rax | This mutant line was generated in an ENU screen from the Grainger lab by TILLING (Targeting Induced ... | |
| Xla.Tg(Xtr.ins:dnthra-eGFP)Brown | X. laevis | 5.4 kb X. tropicalis insulin promoter driving dominant negative form of the thyroid receptor alpha (... | ||
| Xtr.sox2em2Horb | X. tropicalis | sox2 | CRISPR knockout of sox2 (SRY-box 2). Custom mutant line. Germ line transmission confirmed. Animals c... | NXR |
| Xtr.Et(krt8:GAL4-VP16,UAS:GFP)Mead | X. tropicalis | Keratin 8 minimal promoter driving expression of GAL4VP16 fusion with UAS GFP reporter gene. Made u... | NXR | |
| Xla.Tg(Xtr.lmo2:Katushka;cryga:Venus)EXRC | X. laevis | 4775bp X. tropicalis (Xtr) LIM domain only 2 (lmo2) promoter driving expression of Katushka (TurboF... | ||
| Xtr.Et(eef1a1:GFP)Hbr,Cen,Fol,Bru Mead | X. tropicalis | Tol2 transposon harboring a Xenopus eef1a1 (eukaryotic translation elongation factor 1 alpha 1) pro... | NXR | |
| Xtr.eomesem2Horb | X. tropicalis | eomes | CRISPR knockout of eomes (eomesodermin). Germline transmission confirmed. Animals carry a 4 base pai... | NXR |
| Xla.Tg(tubb2b:Katushka;cryga:Venus,GFP)2EXRC | X. laevis | 3481bp Neural-Beta-tubulin (NBT) promoter and 5'UTR driving expression of Katushka (TurboFP-C); mark... | ||
| Xtr.tyremOchi | X. tropicalis | tyr | An albino line with CRISPR/Cas9-targeted mutation in tyrosinase (tyr) gene, made by the Ochi Lab. Th... | NBRP |
| Xtr.icam5emHorb | X. tropicalis | icam5 | CRISPR knockout of icam5 (intercellular adhesion molecule 5), Germ line transmission confirmed. Anim... | NXR |
| Xla.Tg(pax3:Katushka;cryga:Venus)EXRC | X. laevis | 2916bp X. laevis paired box 3 (pax3) promoter driving expression of Katushka. pax3 promoter from Ma... | ||
| Xtr.runx1em1Horb | X. tropicalis | runx1 | CRISPR knockout of runx1(runt related transcription factor 1). Germ line transmission confirmed. Ani... | NXR |
| Xla.wnt11emHorb | X. laevis | wnt11.L wnt11.S | Double CRISPR knockout of wnt11 (Wnt family member 11) in X. laevis, Confirmed germline transmission... | NXR |
| Xla.Tg(CAG:GFP)Mead | X. laevis | NXR | ||
| Xla.pkhd1emHorb | X. laevis | pkhd1.L | CRISPR knockout of pkhd1 (PKHD1, fibrocystin/polyductin), Germ line transmission confirmed. Animals ... | NXR |
| Xtr.Tg(myf5:eGFP)Ogino | X. tropicalis | A X. tropicalis Tg line carrying a myf5 promoter driving EGFP expression in somite, made by the Ogin... | NBRP |
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