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XB-LINE-1427
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Line Name: Xla.pkd1em2Horb
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| Summary | |
|---|---|
| Synonym: | Xla.pkd1tmHorb |
| Species: | Xenopus laevis |
| Background Strain: | Xla.J-strainNXR |
| Paternal Line: | |
| Maternal Line: | |
| Description: | CRISPR knockout of pkd1 (polycystin 1, transient receptor potential channel interacting). Germ line transmission confirmed. Animals carry a 281 base pair deletion. Contact the NXR for more details. Custom mutant generated by Horb Lab. |
| Phenotype Description: | -281 base pair mutation sequence ATGTTGTTGGGTTA----(281)--- ATAATTA. Embryos develop abnormal kidneys (dilated tubules appear after stage 40), cystic kidneys in F0s. Associated with human autosomal dominant polycystic kidney disease. |
| Color Morph: | pigmented |
| Breeding Type: | OUTBRED |
| Lab of Origin: | Horb Lab |
| Line Type: | Mutant |
| Mutated Gene(s): | pkd1.L |
| MTA Required: | No |
| Public: | Yes |
| Catalogue Number: | NXR_2170 |
| Stock Center | RRID | Generation | Availability | Mutant Details | |
|---|---|---|---|---|---|
| NXR (US) | NXR_2170 | F1 | Order | ||
| EXRC (Europe) | |||||
| NBRP (Japan) | |||||
| XLRRI (US) | |||||
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