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XB-LINE-2343
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Line Name: Xtr.lrrk2em3NXR
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| Summary | |
|---|---|
| Synonym: | |
| Species: | Xenopus tropicalis |
| Background Strain: | Xtr.Nigerian1NXR |
| Paternal Line: | Xtr.lrrk2em2NXR |
| Maternal Line: | Xtr.lrrk2em2NXR |
| Description: | CRISPR knockout of lrrk2 (leucine-rich repeat kinase 2 ). Germ line transmission confirmed. New line developed with guide upstream of previous lrrk2 target site (see XB-LINE-1829 and XB-LINE-2342). +4 base pair line (XB-LINE-2342) was intercrossed and embryos were injected with new guide. Animals carry a 7 base pair deletion in lrrk2. Contact NXR for more details. |
| Phenotype Description: | -7 base pair mutation sequence CAATGCACC-------AACACTCTTGGTAT. Associated with late onset Parkinson's disease. |
| Color Morph: | pigmented |
| Breeding Type: | OUTBRED |
| Lab of Origin: | NXR |
| Line Type: | Mutant |
| Mutated Gene(s): | lrrk2 |
| MTA Required: | No |
| Public: | Yes |
| Catalogue Number: | NXR_3221 |
| Stock Center | RRID | Generation | Availability | Mutant Details | |
|---|---|---|---|---|---|
| NXR (US) | NXR_3221 | F1 | Order | ||
| EXRC (Europe) | |||||
| NBRP (Japan) | |||||
| XLRRI (US) | |||||
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