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XB-IMG-130821

Xenbase Image ID: 130821


Fig. 9. Repression of xBMP-3b and cerberus leads to impaired gastrulation movements. Lineage of cells targeted by MOs and expression of marker genes were monitored at gastrula, neurula and tadpole stages. (Left) Embryos injected with MOs for both xBMP-3b and cerberus. (Right) Control embryos injected with globin MO. Light blue staining represents cells targeted by MOs. Brown staining represents expression of markers as indicated on right corner. Dorsal side faces top in panels of gastrula and tadpole, and anterior side faces top in panels of neurula. Injection of MOs for xBMP-3b and cerberus did not affect dorsal lip formation and expression of organizer genes at beginning of gastrulation, but led to delayed blastopore closure and downregulation of Otx2 expression by neurula stage. Consequently, suppressing xBMP-3b and cerberus functions elevated expression of a ventral–posterior marker, Xcad1.

Image published in: Hino J et al. (2003)

Copyright © 2003. Image reproduced with permission of the Publisher, Elsevier B. V.

GeneCloneSynonymsSpeciesStage(s)Tissue
otx2.S Xotx2, otx-2, Xotx-2, otxA, otx2-a, otx2-bX.laevisThroughout NF stage 11dorsal marginal zone
cer1.S xcer, xcer-1, xcer1, cer, Cerberus, tCerberus, cer-1, dand4X.laevisThroughout NF stage 11dorsal marginal zone
otx2.S Xotx2, otx-2, Xotx-2, otxA, otx2-a, otx2-bX.laevisThroughout NF stage 20pre-chordal neural plate
gdf10.L gdf-10, bmp3b, bmp-3bX.laevisThroughout NF stage 20neural plate border
hoxc9-like.L X.laevisThroughout NF stage 28spinal cord
posterior
cdx2.L cdx3-like, cdx-2, cad2, Xcaudal2, xcad2X.laevisThroughout NF stage 28tail bud
post-anal gut

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